Biological evaluation of folic acid functionalized nano-zeolitic imidazolate framework-8 for cancer therapy

IF 2.2 4区化学 Q3 CHEMISTRY, PHYSICAL

Colloid and Polymer Science Pub Date : 2024-12-14 DOI:10.1007/s00396-024-05357-5

Lai Xie Yong, Muhamad Ibrahim Abdul Malek, Azren Aida Asmawi, Rosniza Razali, Afiq Azil, Nur Aininie Yusoh, Nurul Akmarina Mohd Abdul Kamal

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引用次数: 0

Abstract

Conventional chemotherapy often results in toxicity to normal cells and hampers cancer treatment efficacy. Cancer targeting via surface-functionalized nanocarrier offers an excellent opportunity for tackling this unwanted issue. However, a comprehensive understanding of its toxicity and safety in biological entities remains limited. In this study, we report the cancer-selectivity of surface-functionalized nano-zeolitic imidazolate framework-8 (FA@nZIF-8) and its safety characteristics in small organisms including zebrafish embryos and brine shrimp. The FA@nZIF-8 exhibited higher selectivity (3.95) towards cancer cells (MCF7) compared to pure nZIF-8. Moreover, this functionalized nano-ZIF-8 not only enhanced permeability performance but also appeared to be a significant survivability advantage, 80% (P < 0.001) with a higher survival rate compared with pure nZIF-8 at the 96-h mark. No scoliosis appeared in healthy zebrafish embryos for both nanoparticle systems. Monitoring brine shrimps showed minimal toxicity induction at a certain level of concentration. This study suggests that surface-functionalized FA@nZIF-8, with its cancer-selective behavior and promising safety characteristics, has bright potential for further exploration in cancer therapy.

Graphical Abstract

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用于癌症治疗的叶酸功能化纳米沸石咪唑盐框架-8 的生物学评估

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来源期刊

Colloid and Polymer Science 化学-高分子科学

CiteScore

4.60

自引率

4.20%

发文量

111

审稿时长

2.2 months

期刊介绍： Colloid and Polymer Science - a leading international journal of longstanding tradition - is devoted to colloid and polymer science and its interdisciplinary interactions. As such, it responds to a demand which has lost none of its actuality as revealed in the trends of contemporary materials science.