Biological evaluation of folic acid functionalized nano-zeolitic imidazolate framework-8 for cancer therapy

IF 2.2 4区化学 Q3 CHEMISTRY, PHYSICAL

Colloid and Polymer Science Pub Date : 2024-12-14 DOI:10.1007/s00396-024-05357-5

Lai Xie Yong, Muhamad Ibrahim Abdul Malek, Azren Aida Asmawi, Rosniza Razali, Afiq Azil, Nur Aininie Yusoh, Nurul Akmarina Mohd Abdul Kamal

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引用次数: 0

Abstract

Conventional chemotherapy often results in toxicity to normal cells and hampers cancer treatment efficacy. Cancer targeting via surface-functionalized nanocarrier offers an excellent opportunity for tackling this unwanted issue. However, a comprehensive understanding of its toxicity and safety in biological entities remains limited. In this study, we report the cancer-selectivity of surface-functionalized nano-zeolitic imidazolate framework-8 (FA@nZIF-8) and its safety characteristics in small organisms including zebrafish embryos and brine shrimp. The FA@nZIF-8 exhibited higher selectivity (3.95) towards cancer cells (MCF7) compared to pure nZIF-8. Moreover, this functionalized nano-ZIF-8 not only enhanced permeability performance but also appeared to be a significant survivability advantage, 80% (P < 0.001) with a higher survival rate compared with pure nZIF-8 at the 96-h mark. No scoliosis appeared in healthy zebrafish embryos for both nanoparticle systems. Monitoring brine shrimps showed minimal toxicity induction at a certain level of concentration. This study suggests that surface-functionalized FA@nZIF-8, with its cancer-selective behavior and promising safety characteristics, has bright potential for further exploration in cancer therapy.

Graphical Abstract

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用于癌症治疗的叶酸功能化纳米沸石咪唑盐框架-8 的生物学评估

常规化疗对正常细胞有毒性，影响肿瘤治疗效果。通过表面功能化纳米载体的癌症靶向为解决这一问题提供了一个极好的机会。然而，对其在生物实体中的毒性和安全性的全面了解仍然有限。在这项研究中，我们报道了表面功能化纳米沸石咪唑酸框架-8 （FA@nZIF-8）的癌症选择性及其在包括斑马鱼胚胎和盐水虾在内的小生物中的安全性。与纯nZIF-8相比，FA@nZIF-8对癌细胞（MCF7）具有更高的选择性（3.95）。此外，这种功能化的纳米zif -8不仅增强了透气性，而且在存活能力方面也有显著的优势，在96小时时，与纯nZIF-8相比，存活率提高了80% （P < 0.001）。两种纳米颗粒系统均未在健康斑马鱼胚胎中出现脊柱侧凸。对卤虾的监测表明，在一定浓度下，其毒性诱导最小。该研究表明，表面功能化FA@nZIF-8具有癌症选择性行为和良好的安全性，在癌症治疗中具有广阔的探索潜力。图形抽象

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来源期刊

Colloid and Polymer Science 化学-高分子科学

CiteScore

4.60

自引率

4.20%

发文量

111

审稿时长

2.2 months

期刊介绍： Colloid and Polymer Science - a leading international journal of longstanding tradition - is devoted to colloid and polymer science and its interdisciplinary interactions. As such, it responds to a demand which has lost none of its actuality as revealed in the trends of contemporary materials science.