Novel probe with iRGD integrated graphene oxide nanoparticles and labeled with 131I for detection of thyroid papillary carcinoma cells

IF 1.5 3区化学 Q3 CHEMISTRY, ANALYTICAL

Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2025-01-29 DOI:10.1007/s10967-025-09985-1

Pinghui Li, Jiaojiao Feng, Tingting Wang, Shici Yang, Xiaoming Cai, Yaohui Zhang, Jinming Cai, Gaohong Zhu

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引用次数: 0

Abstract

Integrating multiple targets and hence bio-distribution effectively for papillary thyroid carcinoma (PTC) treatment remains a significant challenge, which can be addressed by using suitable nano-scale materials. Herein, iRGD-modified graphene oxide (GO) loaded ¹³¹I are developed for the specific treatment of PTC strengthened integrin targeting. Fine structural characteristics of GO and GO-iRGDs were characterized by fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEC), Raman spectrum and X-ray photoelectron spectroscopy (XPS). The results showed that there were characteristic peaks and chemical bonds on GO and GO-iRGDs by FT-IR, the D-peak and G-peak of GO disappeared by Raman spectrum and C-N bond with iRGD of GO-iRGDs were strong by XPS. These ¹³¹I-GO-iRGDs and ¹³¹I-GOs were taken up by PTC cell (TPC-1, BCPAP, and IHH-4) through endocytosis after 48 h and 72 h in cell uptake test, especially the uptake rate of ¹³¹I-GO50-iRGD was the highest. The CCK-8 cytotoxicity test of ¹³¹I-GO-iRGDs and ¹³¹I-GOs showed that these nanoparticles toxicity were higher than that of Na¹³¹I and finally promoted PTC death. In vitro data verified the targeting mechanism of GO and ¹³¹I for PTC cell line is based on the relevant advantages of binding cell, followed by iRGD-endowed cell surface transport. The tailored design of GO-iRGDs validates a promising paradigm for radioisotope (131-iodine) delivery to combat PTC resistance and metastasis resulting from poor target access for effective combination therapy.

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来源期刊

Journal of Radioanalytical and Nuclear Chemistry 化学-分析化学

CiteScore

2.80

自引率

18.80%

发文量

504

审稿时长

2.2 months

期刊介绍： An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.