Actinium purification from elemental components of stainless steel and aluminum

IF 1.5 3区 化学 Q3 CHEMISTRY, ANALYTICAL
Jan Klouda, Sara L. Adelman, Kelly E. Aldrich, Stosh A. Kozimor, Mila Nhu Lam, Laura M. Lilley, Veronika Mocko, Sara L. Thiemann
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引用次数: 0

Abstract

Radioisotopes of actinium are valuable because of their potential use in the medical industry. Actinium-225 shows promise for treating disease—like cancer—via targeted alpha therapy (TAT), and the longer-lived actinium-227 is the parent of two radionuclides with potential application in TAT radiopharmaceuticals, thorium-227 and radium-223. Continuing progress in the development of these medical applications requires robust and diverse methods for extracting and purifying actinium from a wide range of matrices. To define the strengths and limitations of separation methods commonly employed in actinium processing, we characterized the performance of ion exchange and extraction chromatographic steps for removing contaminants found in stainless steel (chromium, iron, nickel, and silicon) and aluminum from actinium-227. While AG-MP1 anion exchange resin with HCl(aq) successfully removed iron, cation exchanger AG 50W-X8 removed most other contaminants. The most persistent contaminant was aluminum, which was removed using a DGA Normal extraction resin. These results are presented within the context of applying that methodology toward actinium purification strategies.

从不锈钢和铝的元素成分中提纯锕
锕的放射性同位素因其在医疗工业中的潜在用途而具有价值。锕-225有望通过靶向α疗法(TAT)治疗类似癌症的疾病,而寿命更长的锕-227是两种放射性核素的母体,钍-227和镭-223在TAT放射性药物中有潜在的应用。这些医学应用的持续发展需要从广泛的基质中提取和纯化锕的强大和多样化的方法。为了确定锕处理中常用的分离方法的优势和局限性,我们对离子交换和萃取色谱步骤的性能进行了表征,以从锕-227中去除不锈钢(铬、铁、镍和硅)和铝中的污染物。AG- mp1阴离子交换树脂与HCl(aq)成功地去除了铁,阳离子交换剂AG 50W-X8去除了大部分其他污染物。最持久的污染物是铝,使用DGA正常提取树脂去除。这些结果是在应用该方法对锕纯化策略的背景下提出的。
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来源期刊
CiteScore
2.80
自引率
18.80%
发文量
504
审稿时长
2.2 months
期刊介绍: An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.
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