Cerebellum as a neural substrate for impoverishment in early psychosis

IF 2 3区 心理学 Q3 BEHAVIORAL SCIENCES
Eric Toyota , Michael Mackinley , Angelica M. Silva , Yuchao Jiang , Tyler C. Dalal , Caroline Nettekoven , Lena Palaniyappan
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引用次数: 0

Abstract

Background

Formal Thought Disorder and includes both positive (i.e., disorganized speech) and negative (i.e., impoverished speech) symptoms. Emerging evidence suggests that the cerebellum plays a critical role in cognitive functions, including language processing. This study leverages Natural Language Processing to objectively measure language disturbances in patients with first-episode psychosis and investigates the relationship between these disturbances and cerebellar structure.

Methods

Fifty-four patients with schizophrenia, either drug-naïve or minimally medicated, were recruited from an early psychosis program. Impoverished thought was assessed using the Thought Language Index while lexico-semantic features (affect, cognitive, linguistic, perception, time) were identified from speech samples analyzed using the Linguistic Inquiry Word Count-22 software. Structural cerebellar analysis was completed on 7.0 Tesla MRI scans using voxel-based morphometry (VBM) to measure global and regional grey matter volume changes.

Results

Linear regression analysis revealed that reduced perceptual word usage was the strongest predictor of impoverished thinking. Correlational analysis identified reduced cerebellar volumes in patients with lower LIWC-based perception scores. VBM localized this relationship to a cluster in the right posterolateral cerebellar hemisphere, an area related to executive demand and verb generation function.

Conclusion

The cerebellum contributes to impoverished thinking in early psychosis, likely by influencing the lexical expression of perceptual experiences. This underscores the cerebellum's role in higher-order cognitive processes relevant to psychotic disorders and its potential as a therapeutic target for language and cognitive deficits in schizophrenia.
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来源期刊
Neuropsychologia
Neuropsychologia 医学-行为科学
CiteScore
5.10
自引率
3.80%
发文量
228
审稿时长
4 months
期刊介绍: Neuropsychologia is an international interdisciplinary journal devoted to experimental and theoretical contributions that advance understanding of human cognition and behavior from a neuroscience perspective. The journal will consider for publication studies that link brain function with cognitive processes, including attention and awareness, action and motor control, executive functions and cognitive control, memory, language, and emotion and social cognition.
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