Clinical symptoms and molecular epidemiologic characteristics of varicella patients among children and adults in Ganzhou, China.

IF 4 3区 医学 Q2 VIROLOGY
Ting Zeng, Chao-Xian Lian, Xiao-Yi Zhang, Ping-Qing Liu, Jian Ao, Gang-Feng Zhou, Xiao-Dong Chen, Dan-Dan Huang, Dian-Gui Hu, Xin Chen
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引用次数: 0

Abstract

Background: Varicella-zoster virus (VZV) is highly transmissible; however, there are limited studies in China.

Methods: The clinical symptoms, disease progression, and laboratory test results of varicella patients among children and adults diagnosed at Ganzhou Fifth People's Hospital from August 2021 to December 2022 were analysed retrospectively. Genetic polymorphisms in the open reading frame (ORF) 22 and ORF62 fragments of VZV isolates were analysed using molecular epidemiological methods.

Results: Thirty-nine varicella patients were included in this study, 26 of them were children and 13 of them were adults. The incidence of discomfort and complications was significantly greater in adults than in children (P < 0.05). Four adults developed severe disease, one of whom died, with no cases of severe disease or death among children. The 32 VZV clinical isolates were all Clade 2 wild-type strains. Four variant isolates from children had eight base mutations, five of which were missense; two variant isolates from adults had four base mutations, all of which were missense.

Conclusions: The risk of developing severe disease or even death after VZV infection in adults was greater than that in children. There is an urgent need for more studies focusing on the differences in the pathogenicity of VZV in different age groups.

背景:水痘-带状疱疹病毒(VZV)具有高度传播性,但在中国的研究有限:水痘-带状疱疹病毒(VZV)具有高度传播性,但在中国的研究有限:方法:回顾性分析2021年8月至2022年12月在赣州市第五人民医院确诊的儿童和成人水痘患者的临床症状、疾病进展和实验室检查结果。采用分子流行病学方法分析了VZV分离株开放阅读框(ORF)22和ORF62片段的基因多态性:本研究共纳入 39 例水痘患者,其中 26 例为儿童,13 例为成人。成人不适症状和并发症的发生率明显高于儿童(P 结论:成人水痘患者的不适症状和并发症的发生率明显高于儿童:成人感染 VZV 后出现严重疾病甚至死亡的风险高于儿童。迫切需要开展更多研究,重点关注 VZV 在不同年龄组的致病性差异。
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来源期刊
Virology Journal
Virology Journal 医学-病毒学
CiteScore
7.40
自引率
2.10%
发文量
186
审稿时长
1 months
期刊介绍: Virology Journal is an open access, peer reviewed journal that considers articles on all aspects of virology, including research on the viruses of animals, plants and microbes. The journal welcomes basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines and anti-viral therapies. The Editorial policy of Virology Journal is to publish all research which is assessed by peer reviewers to be a coherent and sound addition to the scientific literature, and puts less emphasis on interest levels or perceived impact.
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