{"title":"Clinical symptoms and molecular epidemiologic characteristics of varicella patients among children and adults in Ganzhou, China.","authors":"Ting Zeng, Chao-Xian Lian, Xiao-Yi Zhang, Ping-Qing Liu, Jian Ao, Gang-Feng Zhou, Xiao-Dong Chen, Dan-Dan Huang, Dian-Gui Hu, Xin Chen","doi":"10.1186/s12985-025-02661-6","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Varicella-zoster virus (VZV) is highly transmissible; however, there are limited studies in China.</p><p><strong>Methods: </strong>The clinical symptoms, disease progression, and laboratory test results of varicella patients among children and adults diagnosed at Ganzhou Fifth People's Hospital from August 2021 to December 2022 were analysed retrospectively. Genetic polymorphisms in the open reading frame (ORF) 22 and ORF62 fragments of VZV isolates were analysed using molecular epidemiological methods.</p><p><strong>Results: </strong>Thirty-nine varicella patients were included in this study, 26 of them were children and 13 of them were adults. The incidence of discomfort and complications was significantly greater in adults than in children (P < 0.05). Four adults developed severe disease, one of whom died, with no cases of severe disease or death among children. The 32 VZV clinical isolates were all Clade 2 wild-type strains. Four variant isolates from children had eight base mutations, five of which were missense; two variant isolates from adults had four base mutations, all of which were missense.</p><p><strong>Conclusions: </strong>The risk of developing severe disease or even death after VZV infection in adults was greater than that in children. There is an urgent need for more studies focusing on the differences in the pathogenicity of VZV in different age groups.</p>","PeriodicalId":23616,"journal":{"name":"Virology Journal","volume":"22 1","pages":"44"},"PeriodicalIF":4.0000,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844084/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Virology Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12985-025-02661-6","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VIROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Varicella-zoster virus (VZV) is highly transmissible; however, there are limited studies in China.
Methods: The clinical symptoms, disease progression, and laboratory test results of varicella patients among children and adults diagnosed at Ganzhou Fifth People's Hospital from August 2021 to December 2022 were analysed retrospectively. Genetic polymorphisms in the open reading frame (ORF) 22 and ORF62 fragments of VZV isolates were analysed using molecular epidemiological methods.
Results: Thirty-nine varicella patients were included in this study, 26 of them were children and 13 of them were adults. The incidence of discomfort and complications was significantly greater in adults than in children (P < 0.05). Four adults developed severe disease, one of whom died, with no cases of severe disease or death among children. The 32 VZV clinical isolates were all Clade 2 wild-type strains. Four variant isolates from children had eight base mutations, five of which were missense; two variant isolates from adults had four base mutations, all of which were missense.
Conclusions: The risk of developing severe disease or even death after VZV infection in adults was greater than that in children. There is an urgent need for more studies focusing on the differences in the pathogenicity of VZV in different age groups.
期刊介绍:
Virology Journal is an open access, peer reviewed journal that considers articles on all aspects of virology, including research on the viruses of animals, plants and microbes. The journal welcomes basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines and anti-viral therapies.
The Editorial policy of Virology Journal is to publish all research which is assessed by peer reviewers to be a coherent and sound addition to the scientific literature, and puts less emphasis on interest levels or perceived impact.