Safety outcomes of a mobile laminar airflow device to perform intravitreal injections: a 3-year retrospective study

IF 3.9 3区医学 Q1 INFECTIOUS DISEASES

Journal of Hospital Infection Pub Date : 2025-02-20 DOI:10.1016/j.jhin.2025.02.007

M.M. Carlà , A. Scampoli , L. Governatori , G. Grieco , R. Catalani , W. Calcatelli , T. Caporossi

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引用次数: 0

Abstract

Background

The increasing demand for intravitreal injections (IVIs) necessitates exploring efficient and safe alternatives to traditional operating rooms (ORs). The use of mobile laminar airflow (LAF) devices has emerged as a potential solution to create a sterile environment for IVIs outside the OR. This study investigated the safety outcomes of the Operio mobile LAF device to perform IVIs in a non-OR setting.

Methods

This retrospective study included 1420 patients who received a total of 6638 IVIs between January 2021 and December 2024 at Ospedale Fatebenefratelli Isola Tiberina – Gemelli Isola in Rome, Italy. The Operio mobile LAF device was positioned beside the operating table, directing air flow towards the surgical area. A standardized protocol was followed for patient preparation, anaesthesia, IVI administration and post-injection care. The primary outcome was the incidence of endophthalmitis.

Results

Antivascular endothelial growth factor agents constituted 96% (6369/6638) of all IVIs. Corticosteroids accounted for the remaining 4% (269/6638) of IVIs. One case of endophthalmitis following an IVI with Mvasi was observed among the 6638 IVIs administered during the study period, a rate of 0.015%. Other complications, such as subconjunctival haemorrhage (386 eyes) and transient ocular hypertension (57 eyes), were not linked with use of the Operio mobile LAF device.

Conclusion

Using a portable LAF device, such as the Operio mobile LAF device, for IVIs in a non-OR setting is a safe and effective alternative to traditional ORs.

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来源期刊

Journal of Hospital Infection 医学-传染病学

CiteScore

12.70

自引率

5.80%

发文量

271

审稿时长

19 days

期刊介绍： The Journal of Hospital Infection is the editorially independent scientific publication of the Healthcare Infection Society. The aim of the Journal is to publish high quality research and information relating to infection prevention and control that is relevant to an international audience. The Journal welcomes submissions that relate to all aspects of infection prevention and control in healthcare settings. This includes submissions that: provide new insight into the epidemiology, surveillance, or prevention and control of healthcare-associated infections and antimicrobial resistance in healthcare settings; provide new insight into cleaning, disinfection and decontamination; provide new insight into the design of healthcare premises; describe novel aspects of outbreaks of infection; throw light on techniques for effective antimicrobial stewardship; describe novel techniques (laboratory-based or point of care) for the detection of infection or antimicrobial resistance in the healthcare setting, particularly if these can be used to facilitate infection prevention and control; improve understanding of the motivations of safe healthcare behaviour, or describe techniques for achieving behavioural and cultural change; improve understanding of the use of IT systems in infection surveillance and prevention and control.