The effect of vitamin D supplementation on endothelial function: An umbrella review of interventional meta-analyses.

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-01-25 DOI:10.1016/j.numecd.2025.103871

Yirui Chen, Dandan Chen, Ye Peng, Manling Wang, Wensong Wang, Fangfang Shi, Yanzhong Wang, Liqun Hua

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引用次数: 0

Abstract

Aims: There is no consensus in the existing literature regarding the effect of vitamin D supplementation on endothelial function. This umbrella review aimed to assess meta-analyses of randomized controlled trials (RCTs) conducted in this field.

Data synthesis: We systematically searched English-language databases, including PubMed, Embase, Scopus, and Web of Science, up to January 2024. Flow-Mediated Dilation (FMD), Pulse Wave Velocity (PWV), and Augmentation Index (AIx) were the primary endpoints evaluated. A total of 16 meta-analyses were included in the review. The results indicated that vitamin D supplementation significantly improved FMD as assessed by Standardized Mean Difference (SMD) (SMD = 0.72, 95 % CI: 0.34, 1.11; p < 0.001; I² = 79.4 %, p < 0.001) and Weighted Mean Difference (WMD) (WMD = 1.91; 95 % CI: 0.66, 3.16; p = 0.003; I² = 94.5 %, p < 0.001). PWV also showed a modest but significant improvement (SMD = -0.06, 95 % CI: -0.12, -0.00; p = 0.03; I² = 0.0 %, p = 0.66). However, vitamin D had no significant impact on AIx based on SMD (SMD = -0.03, 95 % CI: -0.13, 0.06; p = 0.48; I² = 0.0 %, p = 0.49) or WMD (WMD = 0.02, 95 % CI: -2.22, 2.25; p = 0.98; I² = 29.2 %, p = 0.23).

Conclusion: These findings suggest that vitamin D supplementation may be a beneficial intervention for improving endothelial function, particularly in populations with low FMD. The effects on PWV were modest, while AIx remained unaffected.

Registration number: PROSPERO, CRD42024451215.

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补充维生素 D 对内皮功能的影响：干预性荟萃分析综述。

目的：关于维生素 D 补充剂对内皮功能的影响，现有文献尚未达成共识。本综述旨在评估在该领域进行的随机对照试验（RCT）的荟萃分析：我们系统地检索了截至 2024 年 1 月的英文数据库，包括 PubMed、Embase、Scopus 和 Web of Science。评估的主要终点是血流介导的扩张（FMD）、脉搏波速度（PWV）和增强指数（AIx）。共有 16 项荟萃分析被纳入综述。结果表明，根据标准化均值差（SMD）评估，补充维生素 D 可明显改善 FMD（SMD = 0.72，95 % CI：0.34，1.11；P 2 = 79.4 %，P 2 = 94.5 %，P 2 = 0.0 %，P = 0.66）。然而，根据SMD（SMD = -0.03，95 % CI：-0.13，0.06；p = 0.48；I2 = 0.0 %，p = 0.49）或WMD（WMD = 0.02，95 % CI：-2.22，2.25；p = 0.98；I2 = 29.2 %，p = 0.23），维生素D对AIx没有明显影响：这些研究结果表明，补充维生素 D 可能是改善血管内皮功能的有益干预措施，尤其是在 FMD 较低的人群中。对脉搏波速度的影响不大，而AIx则不受影响：prospero，CRD42024451215。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Metabolism and Cardiovascular Diseases 医学-内分泌学与代谢

CiteScore

6.80

自引率

2.60%

发文量

332

审稿时长

57 days

期刊介绍： Nutrition, Metabolism & Cardiovascular Diseases is a forum designed to focus on the powerful interplay between nutritional and metabolic alterations, and cardiovascular disorders. It aims to be a highly qualified tool to help refine strategies against the nutrition-related epidemics of metabolic and cardiovascular diseases. By presenting original clinical and experimental findings, it introduces readers and authors into a rapidly developing area of clinical and preventive medicine, including also vascular biology. Of particular concern are the origins, the mechanisms and the means to prevent and control diabetes, atherosclerosis, hypertension, and other nutrition-related diseases.