Feasibility and comparison of 3D modified rosette ultra-short echo time (PETALUTE) with conventional weighted acquisition in ³¹P-MRSI.

IF 3.9 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Scientific Reports Pub Date : 2025-02-22 DOI:10.1038/s41598-025-90630-y

Brian Bozymski, Xin Shen, Ali Özen, Mark Chiew, M Albert Thomas, William T Clarke, Stephen Sawiak, Ulrike Dydak, Uzay Emir

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Abstract

Phosphorus-31 magnetic resonance spectroscopic imaging (³¹P-MRSI) provides valuable non-invasivein vivoinformation on tissue metabolism but is burdened by poor sensitivity and prolonged scan duration. Ultra-short echo time (UTE) acquisitions minimize signal loss when probing signals with relatively short spin-spin relaxation time (T₂), while also preventing first-order dephasing. Here, a three-dimensional (3D) UTE sequence with a rosette k-space trajectory (PETALUTE) is applied to ³¹P-MRSI at 3T. Conventional weighted MRSI employs highly regular Cartesian k-space sampling, susceptible to substantial artifacts when accelerated via undersampling. In contrast, this novel sequence's "petal-like" pattern offers incoherent sampling more suitable for compressed sensing (CS). These results showcase the competitive performance of PETALUTE against conventional weighted ³¹P-MRSI with simulation, phantom, and in vivo leg muscle comparisons.

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三维修正玫瑰超短回波时间（PETALUTE）与传统加权采集在31P-MRSI中的可行性及比较。

磷-31 磁共振波谱成像（31P-MRSI）可提供宝贵的非侵入性组织代谢信息，但灵敏度低、扫描时间长。超短回波时间（UTE）采集可在探测自旋-自旋弛豫时间（T2）相对较短的信号时最大限度地减少信号损失，同时还能防止一阶去相。在此，我们在 3T 下将带有玫瑰花形 k 空间轨迹（PETALUTE）的三维 (3D) UTE 序列应用于 31P-MRSI。传统的加权 MRSI 采用高度规则的笛卡尔 k 空间采样，通过欠采样加速时容易产生大量伪影。相比之下，这种新型序列的 "花瓣状 "模式提供的不连贯采样更适合压缩传感（CS）。这些结果展示了 PETALUTE 与传统的加权 31P-MRSI 相比，在模拟、模型和体内腿部肌肉对比方面的竞争性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Scientific Reports Natural Science Disciplines-

CiteScore

7.50

自引率

4.30%

发文量

19567

审稿时长

3.9 months

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