Hypertension inhibition by Dubosiella newyorkensis via reducing pentosidine synthesis.

IF 7.8 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Tian-Hao Liu, Ming-Hao Chen, Chen-Yang Zhang, Ting Xie, Sitong Zhang, Haining Hao, Zhen-Yu Bai, Yu-Zheng Xue, Jiong-Wei Wang, Ya Xiao, Hong Wei, Li-Guo Chen
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Abstract

Gut dysbiosis has been associated with hypertension. Herein, we aimed to discover the potential association between gut microbiota and high-salt diet (HSD) induced endothelial dysfunction in conventional hypertensive mice. Dubosiella newyorkensis was found highly sensitive to salt in HSD-induced hypertension. The salt-sensitive nature of Dubosiella newyorkensis was confirmed by bacteria culture in vitro. Oral Dubosiella newyorkensis in HSD-induced hypertensive mice decreased blood pressure, inhibited activation of vascular endothelium, attenuated inflammation and alleviated intestinal vascular barrier injury. Similar effects of Dubosiella newyorkensis were observed in germ-free mice. Interestingly, serum pentosidine was found to function as a biomarker for Dubosiella newyorkensis in response to HSD in both metabolic modes. Supplement of pentosidine, deteriorated hypertension and vascular endothelial damage. Differential genes enriched in the glycerophospholipid metabolism were markedly altered in cultured bacteria. Our study has identified Dubosiella newyorkensis as a new salt-sensitive gut microbe that inhibits pentosidine production thereby alleviating hypertension.

纽约杜波氏菌通过减少戊苷合成抑制高血压。
肠道生态失调与高血压有关。在此,我们旨在发现肠道微生物群与高盐饮食(HSD)诱导的常规高血压小鼠内皮功能障碍之间的潜在关联。在高血压患者中发现纽约杜波氏菌对盐高度敏感。通过体外培养证实了纽约杜波氏菌的盐敏感性。hsd诱导的高血压小鼠口服纽约杜波氏菌可降低血压,抑制血管内皮活化,减轻炎症,减轻肠道血管屏障损伤。在无菌小鼠中也观察到纽约杜波氏菌的类似效果。有趣的是,在两种代谢模式下,血清戊sidine被发现作为纽约杜波氏菌对HSD的生物标志物。戊苷的补充,高血压恶化和血管内皮损伤。在培养的细菌中,甘油磷脂代谢富集的差异基因明显改变。我们的研究已经确定纽约杜波氏菌是一种新的盐敏感肠道微生物,可以抑制戊苷的产生,从而缓解高血压。
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来源期刊
npj Biofilms and Microbiomes
npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology
CiteScore
12.10
自引率
3.30%
发文量
91
审稿时长
9 weeks
期刊介绍: npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.
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