Two new tetralones from the endophytic fungus Annulohypoxylon stygium A888.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-02-22 DOI:10.1080/10286020.2025.2464683

Zhi-Shen Shao, Yu-Chan Chen, Wei-Peng Ma, Sai-Ni Li, Hong-Xin Liu, Wei-Min Zhang, Xiao-Ying Chen

引用次数: 0

Abstract

Two new tetralones, annulohyporins A (1) and B (2), along with thirteen known compounds (3-15), were isolated from the ethyl acetate extract of solid fermentation of the endophytic fungus Annulohypoxylon stygium A888, which was isolated from the medicinal plant Aquilaria sinensis. The structures of annulohyporins A and B were established by detailed analyses of ultraviolet-visible spectroscopy (UV), infrared spectroscopy (IR), mass spectrometry (MS), electronic circular dichroism (ECD) calculations and nuclear magnetic resonance (NMR). Bioactivity assay showed that compounds 3 and 4 had significant α-glucosidase inhibitory activities with IC₅₀ values of 64.00 and 32.90 µM, respectively.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.