Alejandro Llamedo, Pablo Rodríguez, Carolina de Passos, Sandra Freitas-Rodriguez, Ana M Coto, Raquel G Soengas, Rebeca Alonso-Bartolomé
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引用次数: 0
Abstract
This study describes the development of a novel liposomal formulation incorporating 3-O-ethyl-L-ascorbic acid (EAA), a derivative of vitamin C. The EAA-loaded liposomes were fully characterized, particle size and zeta potential values suitable for drug delivery. The skin penetration studies revealed that liposomal formulation enhanced EAA retention in the skin compared to free EAA. Additionally, the impact of topical treatments with liposomal EAA on photo-aging markers in skin explants was investigated. EAA charged liposomes display a protective or stimulatory effect on cellular metabolism. Finally, liposomal EAA have a significant effect on the inflamatory markers, reducing the extracellular matrix degradation associated with UV-induced damage of skin. These findings provide valuable insights into the potential of liposomal formulations for the development of advanced cosmetic products.
期刊介绍：
The Journal of Liposome Research aims to publish original, high-quality, peer-reviewed research on the topic of liposomes and related systems, lipid-based delivery systems, lipid biology, and both synthetic and physical lipid chemistry. Reviews and commentaries or editorials are generally solicited and are editorially reviewed. The Journal also publishes abstracts and conference proceedings including those from the International Liposome Society.
The scope of the Journal includes:
Formulation and characterisation of systems
Formulation engineering of systems
Synthetic and physical lipid chemistry
Lipid Biology
Biomembranes
Vaccines
Emerging technologies and systems related to liposomes and vesicle type systems
Developmental methodologies and new analytical techniques pertaining to the general area
Pharmacokinetics, pharmacodynamics and biodistribution of systems
Clinical applications.
The Journal also publishes Special Issues focusing on particular topics and themes within the general scope of the Journal.
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