Features that distinguish age-related macular degeneration from aging

IF 3 2区医学 Q1 OPHTHALMOLOGY

Experimental eye research Pub Date : 2025-02-20 DOI:10.1016/j.exer.2025.110303

Dorota Skowronska-Krawczyk , Silvia C. Finnemann , Maria B. Grant , Katherine Held , Zhengping Hu , Yuancheng Ryan Lu , Goldis Malek , Florian Sennlaub , Janet Sparrow , Patricia A. D'Amore

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引用次数: 0

Abstract

Age-related macular degeneration (AMD) is a complex, multifactorial retinal degenerative disease that is influenced by both genetic and environmental factors. However, the strongest risk factor for AMD is advanced age. Several physiological processes are observed in aging tissues including a low level of chronic inflammation (inflammaging), changed lipid and energy metabolism, and senescence. Nevertheless, whereas everyone ages, only a subset of the population develops AMD. The purpose of this review is to delineate the differences on a cellular and molecular level between natural aging changes and those observed in AMD. We provide a unique perspective on how genetic and environmental components modulate aging in the eye, as well as the specific role of the aging RPE and retina in the pathogenesis of AMD. Topics discussed include the mechanism of aging and its relation to the mechanism of AMD, current animal models that can be used to recapitulate some aspects of the pathology, and potential interventions that shift the balance towards healthy aging and therefore attenuate, prevent or delay the initiation of the disease.

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区分年龄相关性黄斑变性与衰老的特征。

年龄相关性黄斑变性（AMD）是一种复杂的、多因素的视网膜退行性疾病，受遗传和环境因素的影响。然而，AMD的最大风险因素是高龄。在衰老组织中观察到一些生理过程，包括低水平的慢性炎症（炎症）、脂质和能量代谢的改变以及衰老。然而，尽管每个人都会变老，但只有一小部分人会患上AMD。本综述的目的是在细胞和分子水平上描述自然衰老变化与AMD中观察到的变化之间的差异。我们提供了遗传和环境因素如何调节眼睛老化的独特视角，以及老化的RPE和视网膜在AMD发病机制中的具体作用。讨论的主题包括衰老机制及其与AMD机制的关系，可用于概括病理学某些方面的当前动物模型，以及将平衡转向健康衰老的潜在干预措施，从而减轻，预防或延迟疾病的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental eye research 医学-眼科学

CiteScore

6.80

自引率

5.90%

发文量

323

审稿时长

66 days

期刊介绍： The primary goal of Experimental Eye Research is to publish original research papers on all aspects of experimental biology of the eye and ocular tissues that seek to define the mechanisms of normal function and/or disease. Studies of ocular tissues that encompass the disciplines of cell biology, developmental biology, genetics, molecular biology, physiology, biochemistry, biophysics, immunology or microbiology are most welcomed. Manuscripts that are purely clinical or in a surgical area of ophthalmology are not appropriate for submission to Experimental Eye Research and if received will be returned without review.