Benefits of incorporating plant extracts into a commercially available foundation for daily skin use.

IF 1.6 4区医学 Q3 OPHTHALMOLOGY

Cutaneous and Ocular Toxicology Pub Date : 2025-03-01 Epub Date: 2025-02-22 DOI:10.1080/15569527.2025.2467620

Zhengrui Liao, Shiwen Wen, Lee-Hoon Ho, Thuan-Chew Tan

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引用次数: 0

Abstract

Purpose: This study examined a plant extract (PE) foundation's safety, antioxidant and protective properties. To offer a scientific foundation for the viability of creating 'skincare makeup' and improve the comprehension of cosmetic compositions' efficacy evaluations.

Methods: Cellular assays tested six different concentrations (up to 5%) of the PE for cell viability levels and reactive oxygen species (ROS) levels of human immortalised epidermal cells (HaCaTs). The identified non-cytotoxic concentration (0.5% PE) was then tested by gene assays. A commercial foundation containing 0.5% PE (PEF0.5) was tested for safety, skin protective effectiveness, and user satisfaction.

Results: Compared to the control groups, 0.5% PE had a significant inhibitory effect on the expression level of MMP-1 but promoted the expression of COL1A1, COL3A1, ELN, and AQP3. PEF0.5 significantly (p < 0.05) reduced wrinkles and transepidermal water loss (TEWL) while improving hydration, glossiness, and elasticity for 14 and 28 days. Interestingly, sebum was reduced by PEF0.5 at 28 days without any negative consequences for 28 days. No significant (p > 0.05) differences were detected in the foundation's effectiveness and usability.

Conclusion: Applying PEF0.5 for 28 days may improve the skin barrier function, as indicated by skin TEWL, hydration, wrinkle, elasticity, and sebum content, without any adverse effects.

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将植物萃取精华融入日常皮肤使用的市售粉底中的好处。

目的：研究植物提取物（PE）基质的安全性、抗氧化性和防护性。为创造“护肤彩妆”的可行性提供科学依据，提高对化妆品成分功效评估的理解。方法：细胞试验测试了六种不同浓度（最高5%）的PE对人永生化表皮细胞（HaCaTs）的细胞活力水平和活性氧（ROS）水平的影响。鉴定出的非细胞毒浓度（0.5% PE）通过基因分析进行检测。我们测试了含有0.5% PE （PEF0.5）的商用粉底的安全性、皮肤保护效果和用户满意度。结果：与对照组相比，0.5% PE对MMP-1的表达水平有显著抑制作用，但对COL1A1、COL3A1、ELN、AQP3的表达有促进作用。基金会的有效性和可用性PEF0.5差异显著（p p > 0.05）。结论：PEF0.5涂抹28天，可改善皮肤的TEWL、水合、抗皱、弹性、皮脂含量等指标的屏障功能，无不良反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cutaneous and Ocular Toxicology 医学-毒理学

CiteScore

3.30

自引率

6.20%

发文量

审稿时长

1 months

期刊介绍： Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.