Inflammation, microbiota, and pancreatic cancer.

IF 5.3 2区医学 Q1 ONCOLOGY

Cancer Cell International Pub Date : 2025-02-22 DOI:10.1186/s12935-025-03673-6

XiaoLiang Chen, Feixia Sun, Xuqin Wang, Xiaoqiang Feng, Amir Reza Aref, Yu Tian, Milad Ashrafizadeh, Dengfeng Wu

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引用次数: 0

Abstract

Pancreatic cancer (PC) is a malignancy of gastrointestinal tract threatening the life of people around the world. In spite of the advances in the treatment of PC, the overall survival of this disease in advanced stage is less than 12%. Moreover, PC cells have aggressive behaviour in proliferation and metastasis as well as capable of developing therapy resistance. Therefore, highlighting the underlying molecular mechanisms in PC pathogenesis can provide new insights for its treatment. In the present review, inflammation and related pathways as well as role of gut microbiome in the regulation of PC pathogenesis are highlighted. The various kinds of interleukins and chemokines are able to regulate angiogenesis, metastasis, proliferation, inflammation and therapy resistance in PC cells. Furthermore, a number of molecular pathways including NF-κB, TLRs and TGF-β demonstrate dysregulation in PC aggravating inflammation and tumorigenesis. Therapeutic regulation of these pathways can reverse inflammation and progression of PC. Both chronic and acute pancreatitis have been shown to be risk factors in the development of PC, further highlighting the role of inflammation. Finally, the composition of gut microbiota can be a risk factor for PC development through affecting pathways such as NF-κB to mediate inflammation.

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炎症、微生物群和胰腺癌。

胰腺癌（Pancreatic cancer， PC）是一种严重威胁人类生命的胃肠道恶性肿瘤。尽管在治疗方面取得了进展，但这种疾病在晚期的总生存率低于12%。此外，PC细胞在增殖和转移方面具有侵袭性行为，并且能够产生治疗耐药性。因此，强调PC发病机制的潜在分子机制可以为其治疗提供新的见解。本文就炎症及其相关途径以及肠道菌群在PC发病机制中的调节作用作一综述。各种白细胞介素和趋化因子能够调控PC细胞的血管生成、转移、增殖、炎症和治疗抵抗。此外，包括NF-κB、TLRs和TGF-β在内的许多分子通路在PC加重炎症和肿瘤发生中表现出失调。治疗性调节这些通路可以逆转炎症和PC的进展。慢性和急性胰腺炎已被证明是PC发展的危险因素，进一步强调了炎症的作用。最后，肠道菌群的组成可能通过影响NF-κB等介导炎症的途径成为PC发生的危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell International ONCOLOGY-

CiteScore

10.90

自引率

1.70%

发文量

360

审稿时长

1 months

期刊介绍： Cancer Cell International publishes articles on all aspects of cancer cell biology, originating largely from, but not limited to, work using cell culture techniques. The journal focuses on novel cancer studies reporting data from biological experiments performed on cells grown in vitro, in two- or three-dimensional systems, and/or in vivo (animal experiments). These types of experiments have provided crucial data in many fields, from cell proliferation and transformation, to epithelial-mesenchymal interaction, to apoptosis, and host immune response to tumors. Cancer Cell International also considers articles that focus on novel technologies or novel pathways in molecular analysis and on epidemiological studies that may affect patient care, as well as articles reporting translational cancer research studies where in vitro discoveries are bridged to the clinic. As such, the journal is interested in laboratory and animal studies reporting on novel biomarkers of tumor progression and response to therapy and on their applicability to human cancers.