Cu_2-xO@Ti₃C₂ Integrated Photothermal Nanofibers with Antibacterial, Anti-Inflammatory, and Hemostatic Properties for Promoting Infected Diabetic Wound Healing.

IF 5.4 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Biomaterials Science & Engineering Pub Date : 2025-02-22 DOI:10.1021/acsbiomaterials.4c01936

Tao Liao, Jinxiu Liu, Jia Chen, Zhongjia Liu, Guolie Xie, Ning Guo, Ying Kuang, Linghui Dian, Cao Li, Yun Liu

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引用次数: 0

Abstract

Infected diabetic wounds represent a significant challenge in clinical care due to persistent inflammation and impaired healing. To address these issues, the development of novel wound dressings with both antibacterial and reactive oxygen species (ROS) scavenging properties is essential. Herein, we prepare a novel wound dressing composed of Cu_2-xO nanoparticles decorated on Ti₃C₂ MXene (Cu_2-xO@Ti₃C₂) and integrate it into a poly(vinyl alcohol) (PVA) matrix to form electrospun nanofibers (Cu_2-xO@Ti₃C₂@PVA). Cu_2-xO@Ti₃C₂ exhibits remarkable photothermal conversion efficiency and effective ROS scavenging properties. In vitro experiments demonstrated that Cu_2-xO@Ti₃C₂ effectively kills bacteria upon near-infrared (NIR) irradiation, which can be attributed to the photothermal therapy (PTT) effect of Ti₃C₂. At the same time, the ROS scavenging abilities of both Ti₃C₂ and Cu_2-xO endow Cu_2-xO@Ti₃C₂ with significant in vitro anti-inflammatory effects. As a promising wound dressing, in vivo studies validated the high efficacy of Cu_2-xO@Ti₃C₂@PVA in promoting hemostasis, exerting antibacterial activity, reducing inflammation, and accelerating the healing process of diabetic wounds. This innovative approach provides a comprehensive solution to the multifaceted challenges of diabetic wound healing and paves the way for improved clinical outcomes.

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来源期刊

ACS Biomaterials Science & Engineering Materials Science-Biomaterials

CiteScore

10.30

自引率

3.40%

发文量

413

期刊介绍： ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics: Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture