A Novel RAGE Modulator Induces Soluble RAGE to Reduce BACE1 Expression in Alzheimer's Disease (Adv. Sci. 8/2025)

IF 14.3 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-02-24 DOI:10.1002/advs.202570050

Seung-Hyun Baek, Suji Hong, Eunae Kim, Sunyoung Park, Minyoung Lee, Jinsu Park, Yoonsuk Cho, Hyunjun Yoon, Daeseung Kim, Youngkwang Yun, Youbin Kim, Yoonjung Choi, Keunsoo Kang, Sangyong Jung, Jun Pyo Kim, Eunha Kim, Sang Won Seo, Yong-Keun Jung, Dong-Gyu Jo

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Abstract

Repurposing an Old Drug for Alzheimer's Disease

In article number 2407812, Dong-Gyu Jo and co-workers propose a novel strategy for Alzheimer's disease (AD) treatment, demonstrating that the anticancer agent 6-thioguanosine (6-TG) interacts with the receptor for advanced glycation endproducts (RAGE) to regulate BACE1 expression, thereby reducing Aβ accumulation. The interaction with RAGE increases soluble RAGE (sRAGE) levels, which blocks Aβ-RAGE interactions and reduces neuroinflammatory responses. Increasing sRAGE levels could effectively inhibit the RAGE pathway and reduce Aβ accumulation.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.