Mental Fatigue After Aneurysmal Subarachnoid Hemorrhage: A Prospective 5-Year Follow-Up Study

IF 2.9 3区 医学 Q2 CLINICAL NEUROLOGY
Sandra Bjerkne Wenneberg, Linda Block, Jonatan Oras, Pia Löwhagen Hendén, Jaquette Liljencrantz, Jane Hayden, Helena Odenstedt Hergès
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Abstract

Objectives: Mental fatigue is a common and debilitating symptom following an aneurysmal subarachnoid hemorrhage (aSAH). However, its long-term prevalence and consequences remain unclear. In this longitudinal pilot study, the Mental Fatigue Scale (MFS) was used to evaluate the prevalence, severity, and dynamics of mental fatigue for up to 5 years and to correlate patient demographics and early complications to the development of mental fatigue.

Method: Functional outcomes were scored using the Glasgow Outcome Scale-Extended (GOSE) during telephone interviews 1, 3, and 5 years after aSAH. The MFS questionnaires (maximum score 42, ≥ 10.5 points indicating mental fatigue) were subsequently sent by mail. Patient admission data and events during the acute phase were recorded.

Results: Of 64 included patients, 31 could be assessed at all time points. Mental fatigue (MFS score ≥ 10.5) was present in 58%, 48%, and 52% of the patients at 1, 3, and 5 years, respectively. A significant decrease in the total MFS score was observed between 1 and 5 years (p = 0.025). The proportion of patients experiencing severe mental fatigue halved from 1 to 3 years. The median (range) MFS scores were significantly higher for women (14.5, 0–29.5) than for men (3, 0–17.5) at 1 year (p = 0.043). Compared with patients experiencing loss of consciousness at ictus (LOCi), those without LOCi exhibited a progressive decline in the total MFS score (p = 0.003).

Conclusions: Although total MFS scores significantly improved, mental fatigue was a common and persistent symptom affecting half of the patients up to 5 years following aSAH. Mental fatigue was more prevalent in women than men; further, patients who experienced LOCi during the acute phase improved less over time. Our results highlight the importance of evaluating mental fatigue when assessing patient recovery and long-term outcomes.

Trial Registration: Clinical Trial NCT06239142

Abstract Image

动脉瘤性蛛网膜下腔出血后的精神疲劳:一项前瞻性5年随访研究
目的:精神疲劳是动脉瘤性蛛网膜下腔出血(aSAH)后常见的衰弱症状。然而,其长期流行和后果尚不清楚。在这项纵向试点研究中,使用精神疲劳量表(MFS)来评估长达5年的精神疲劳的患病率、严重程度和动态,并将患者人口统计学和早期并发症与精神疲劳的发展联系起来。方法:在aSAH后1、3和5年的电话访谈中,使用格拉斯哥结局量表扩展(GOSE)对功能结局进行评分。MFS问卷(最高评分42分,≥10.5分表示精神疲劳)随后通过邮件发送。记录患者入院数据和急性期事件。结果:64例患者中,31例在所有时间点均可评估。精神疲劳(MFS评分≥10.5)在1年、3年和5年分别出现在58%、48%和52%的患者中。MFS总评分在1至5年间显著下降(p = 0.025)。经历严重精神疲劳的患者比例在1至3年内减半。1年的MFS评分中位数(范围)女性(14.5,0-29.5)显著高于男性(3,0-17.5)(p = 0.043)。与经历突发性意识丧失(LOCi)的患者相比,没有LOCi的患者在总MFS评分中表现出进行性下降(p = 0.003)。结论:尽管总的MFS评分显著提高,但精神疲劳是一种常见且持续的症状,影响了一半的aSAH患者长达5年。女性比男性更容易出现精神疲劳;此外,在急性期经历LOCi的患者随着时间的推移改善较少。我们的研究结果强调了在评估患者康复和长期预后时评估精神疲劳的重要性。试验注册:临床试验NCT06239142
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来源期刊
Acta Neurologica Scandinavica
Acta Neurologica Scandinavica 医学-临床神经学
CiteScore
6.70
自引率
2.90%
发文量
161
审稿时长
4-8 weeks
期刊介绍: Acta Neurologica Scandinavica aims to publish manuscripts of a high scientific quality representing original clinical, diagnostic or experimental work in neuroscience. The journal''s scope is to act as an international forum for the dissemination of information advancing the science or practice of this subject area. Papers in English will be welcomed, especially those which bring new knowledge and observations from the application of therapies or techniques in the combating of a broad spectrum of neurological disease and neurodegenerative disorders. Relevant articles on the basic neurosciences will be published where they extend present understanding of such disorders. Priority will be given to review of topical subjects. Papers requiring rapid publication because of their significance and timeliness will be included as ''Clinical commentaries'' not exceeding two printed pages, as will ''Clinical commentaries'' of sufficient general interest. Debate within the speciality is encouraged in the form of ''Letters to the editor''. All submitted manuscripts falling within the overall scope of the journal will be assessed by suitably qualified referees.
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