Physical activity may protect myelin via modulation of high-density lipoprotein

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-02-23 DOI:10.1002/alz.14599

Nárlon C. Boa Sorte Silva, Guilherme M. Balbim, Ryan G. Stein, Yi Gu, Roger C. Tam, Elizabeth Dao, Walid Alkeridy, Kevin Lam, Arthur F. Kramer, Teresa Liu-Ambrose

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引用次数: 0

Abstract

INTRODUCTION

Physical activity is associated with greater myelin content in older individuals with cerebral small vessel disease (CSVD), a condition marked by demyelination. However, potential mechanisms underlying this relationship remain understudied.

METHODS

We assessed cross-sectionally whether serum high-density lipoprotein (HDL), low-density lipoprotein, and triglycerides moderated the association between physical activity and in vivo myelin in older individuals with CSVD and mild cognitive impairment.

RESULTS

We included 81 highly educated, community-dwelling older individuals (mean age 74.57 years), 64% of whom were female. Regression models revealed that HDL levels significantly moderated the relationship between physical activity and myelin in the sagittal stratum, wherein higher physical activity levels were linked to greater myelin levels for those with average or high HDL (standardized B [95% CI] = 0.289 [0.087 to 0.491], p = 0.006).

DISCUSSION

Physical activity may promote myelin health partly through HDL. Data from longitudinal studies are needed to confirm our findings.

Highlights

Myelin loss is common in individuals with cerebral small vessel disease (CSVD).
Physical activity was positively associated with myelin in older adults with CSVD.
High-density lipoproteins (HDL) levels were also positively related to myelin.
Physical activity effects on myelin were moderated by HDL levels.

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.