Nanofluids significantly impact the development of pure fluids’ thermal properties in the laboratory and manufacturing settings. This work considers the micropolar nanofluid flow, including thermal radiation through a resistive porous material confined within the channel walls. It investigates the impact of thermal radiation and different physical parameters on micro-rotation and velocity profiles with the effects of heat and mass transmission rates under diverse conditions. Thermal radiation, a form of heat transmission, is a crucial strategy to boost the thermal performance of many systems. Similarly, introducing a porous medium is another criterion for enhancing thermal efficiency. The effects of distinct physical parameters on the fluid flow under various conditions that result from multiple determining factors are examined using a novel homotopy approach. The results are validated through term approximations and compared with the available results to achieve a better agreement.