A New Naphtho[2,3-c]Furan-1(3H)-One Derivative and Anti-Inflammatory and Antioxidant Constituents from Rhamnus kanagusukii

IF 0.8 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2025-02-04 DOI:10.1007/s10600-025-04581-x

Chu-Wen Kuo, Zih-Rong Chen, Hsueh-Yang Huang, Chia-Ching Liaw, Ping-Jyun Sung, Ming-Jen Cheng, Fu-Sen Wu, Jih-Jung Chen

{"title":"A New Naphtho[2,3-c]Furan-1(3H)-One Derivative and Anti-Inflammatory and Antioxidant Constituents from Rhamnus kanagusukii","authors":"Chu-Wen Kuo, Zih-Rong Chen, Hsueh-Yang Huang, Chia-Ching Liaw, Ping-Jyun Sung, Ming-Jen Cheng, Fu-Sen Wu, Jih-Jung Chen","doi":"10.1007/s10600-025-04581-x","DOIUrl":null,"url":null,"abstract":"A new naphtho[2,3-c]furan-1(3H)-one derivative, 6,8,9-trihydroxynaphtho[2,3-c]furan-1(3H)-one (1), has been isolated from the stem bark of Rhamnus kanagusukii, together with eight known compounds, chrysophanol (2), emodin (3), rhamnazin (4), kaempferol (5), apigenin (6), taxifolin (7), ferulic acid (8), and gallic acid (9). The structure of new compound 1 was determined using spectroscopic and MS analyses. Among the isolated compounds, 6,8,9-trihydroxynaphtho[2,3-c]furan-1(3H)-one (1), kaempferol (5), apigenin (6), and taxifolin (7) showed potent inhibition with IC50 values of 19.48 ± 1.52, 20.48 ± 1.84, 16.47 ± 1.25, and 15.44 ± 1.02 μM, respectively, against LPS-induced NO generation. In addition, compounds 5, 6, 7, 8, and 9 also showed potent DPPH radical scavenging activities with IC50 values of 21.11 ± 1.84, 22.47 ± 2.04, 13.02 ± 1.07, 14.54 ± 1.35, and 13.48 ± 1.16 μM respectively.","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 1","pages":"86 - 90"},"PeriodicalIF":0.8000,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry of Natural Compounds","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10600-025-04581-x","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

Abstract

A new naphtho[2,3-c]furan-1(3H)-one derivative, 6,8,9-trihydroxynaphtho[2,3-c]furan-1(3H)-one (1), has been isolated from the stem bark of Rhamnus kanagusukii, together with eight known compounds, chrysophanol (2), emodin (3), rhamnazin (4), kaempferol (5), apigenin (6), taxifolin (7), ferulic acid (8), and gallic acid (9). The structure of new compound 1 was determined using spectroscopic and MS analyses. Among the isolated compounds, 6,8,9-trihydroxynaphtho[2,3-c]furan-1(3H)-one (1), kaempferol (5), apigenin (6), and taxifolin (7) showed potent inhibition with IC₅₀ values of 19.48 ± 1.52, 20.48 ± 1.84, 16.47 ± 1.25, and 15.44 ± 1.02 μM, respectively, against LPS-induced NO generation. In addition, compounds 5, 6, 7, 8, and 9 also showed potent DPPH radical scavenging activities with IC₅₀ values of 21.11 ± 1.84, 22.47 ± 2.04, 13.02 ± 1.07, 14.54 ± 1.35, and 13.48 ± 1.16 μM respectively.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.