Hepatoprotective Flavonolignan from Citrus medica var. sarcodactylis

Abstract

A novel flavonolignan, named 3-hydroxy-7-O-β-D-glucopyranosyl-7′′-(4′′-methoxyphenyl)-8′′-(9′′-ethyl acetate)-flavonolignan (1), along with eight known flavonolignan derivatives (2–9) were isolated from Citrus medica var. sarcodactylis (Siebold ex Hoola van Nooten) Swingle for the first time. These compounds (1–9) were determined by extensive and comprehensive IR, UV, NMR, MS spectral analyses and compared with the reported references. Compounds 1–9 were evaluated for their inhibitory effects against the increases in AST and ALT levels on H₂O₂-induced HepG2 cells. As a result, compounds 1 and 2 displayed moderate hepatoprotective activities.