Treatment of notoedric mange with esafoxolaner, eprinomectin and praziquantel in naturally infested cats under in-home conditions

IF 1.4 Q3 PARASITOLOGY

Veterinary parasitology, regional studies and reports Pub Date : 2025-02-18 DOI:10.1016/j.vprsr.2025.101228

Georgios Sioutas , Athanasios I. Gelasakis , Frederic Beugnet , Elias Papadopoulos

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引用次数: 0

Abstract

Notoedres cati is a contagious, burrowing mite infesting cats that causes mange with intense pruritus and dermatological clinical signs. The aim of the current study was to assess the efficacy of a single administration of NexGard® Combo (esafoxolaner, eprinomectin and praziquantel) against N. cati in naturally infested cats under home conditions. A total of 17 domestic shorthair cats naturally infested with N. cati that were living in the same house were randomly assigned to either the treatment group (n = 9) receiving NexGard® Combo at a dosage of 0.12 mL/kg of their body weight according to label instructions or a negative control group (n = 8) receiving mineral oil at 0.12 mL/kg (Day 0). The cats were separated into different rooms with no contact between the two groups in the same household. Clinical scores, mite counts from skin scrapings and body weights were evaluated on Days −3, 0, 14, 28, 42, and 56. Descriptive statistics (means ± standard deviations) were calculated, and a mixed general linear model was used for statistical analysis. NexGard® Combo showed 100 % efficacy against N. cati, and no live mites were found from Day 14 until the end of the study. Treated cats also exhibited lower clinical scores and higher body weights than the control group by Day 56 (p < 0.05), while placebo-treated cats displayed high mite counts and clinical scores throughout the study. None of the cats displayed any adverse events related to treatment. These findings highlight the efficacy of the combination of esafoxolaner, eprinomectin and praziquantel in treating notoedric mange in cats under in-home conditions.

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猫疥螨是一种侵扰猫的传染性穴居螨，会引起猫疥癣，并伴有剧烈瘙痒和皮肤病临床症状。本研究旨在评估在家庭条件下对自然感染的猫一次性施用 NexGard® Combo（esafoxolaner、eprinomectin 和 praziquantel）对 N. cati 的疗效。将生活在同一屋檐下的17只受到N. cati自然侵扰的短毛猫随机分配到治疗组（n = 9），按照标签说明以每公斤体重0.12毫升的剂量服用NexGard® Combo，或以每公斤体重0.12毫升的剂量服用矿物油的阴性对照组（n = 8）（第0天）。这些猫被分隔在不同的房间里，同一家庭的两组猫之间没有任何接触。在第 3、0、14、28、42 和 56 天评估临床评分、皮肤刮片螨虫计数和体重。计算了描述性统计（平均值 ± 标准差），并采用混合一般线性模型进行统计分析。NexGard® Combo 对猫螨的有效率为 100%，从第 14 天开始直到研究结束都没有发现活的螨虫。与对照组相比，经治疗的猫咪在第 56 天时的临床评分更低，体重更高（p < 0.05），而经安慰剂治疗的猫咪在整个研究期间的螨虫数量和临床评分都很高。没有一只猫出现与治疗相关的不良反应。这些研究结果表明，在家庭条件下，埃沙福兰纳、伊普拉菌素和吡喹酮联合使用可有效治疗猫的艽疥癣。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinary parasitology, regional studies and reports Multiple-

CiteScore

2.90

自引率

7.10%

发文量

126

审稿时长

97 days

期刊介绍： Veterinary Parasitology: Regional Studies and Reports focuses on aspects of veterinary parasitology that are of regional concern, which is especially important in this era of climate change and the rapid and often unconstrained travel of people and animals. Relative to regions, this journal will accept papers of the highest quality dealing with all aspects of disease prevention, pathology, treatment, epidemiology, and control of parasites within the field of veterinary medicine. Also, case reports will be considered as they add to information related to local disease and its control; such papers must be concise and represent appropriate medical intervention. Papers on veterinary parasitology from wildlife species are acceptable, but only if they relate to the practice of veterinary medicine. Studies on vector-borne bacterial and viral agents are suitable, but only if the paper deals with vector transmission of these organisms to domesticated animals. Studies dealing with parasite control by means of natural products, both in vivo and in vitro, are more suited for one of the many journals that now specialize in papers of this type. However, due to the regional nature of much of this research, submissions may be considered based upon a case being made by the author(s) to the Editor. Circumstances relating to animal experimentation must meet the International Guiding Principles for Biomedical Research Involving Animals as issued by the Council for International Organizations of Medical Sciences (obtainable from: Executive Secretary C.I.O.M.S., c/o W.H.O., Via Appia, CH-1211 Geneva 27, Switzerland).