Neuroprotective lindenane sesquiterpenoids from the roots of Lindera aggregata (Sims) Kosterm

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2025-02-20 DOI:10.1016/j.phytochem.2025.114452

Lie-Feng Ma , Shan-Rong Luo , Qian-Qing Liu , Rui-Si Tang , Ning-Yu Chen , Di Luo , Lu Guo , Jia Li , Rui Wu , Zha-Jun Zhan

引用次数: 0

Abstract

Eleven previously undescribed lindenane sesquiterpenoids, lindaggrols A−K (1−11), were isolated from the roots of Lindera aggregata (Sims) Kosterm, together with five known ones. Their structures were elucidated by HR-ESI-MS, NMR, and single-crystal X-ray diffraction analyses. Lindaggrol A (1) is an undescribed rearranged dinor-lindenane with an unprecedented 3/5/5 tricyclic scaffold. All isolated compounds were assayed for their neuroprotective effects against erastin-induced ferroptosis in HT-22 cells. Among them, 3, 12 and 14 exhibited significant neuroprotective activities with EC₅₀ values ranging from 1.4 to 8.7 μM.

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从 Lindera aggregata (Sims) Kosterm 的根中分离出了 11 种以前未曾描述过的椴树烷类倍半萜化合物，即椴树烷 A-K (1-11)，以及 5 种已知的椴树烷类倍半萜化合物。通过 HR-ESI-MS、NMR 和单晶 X 射线衍射分析阐明了它们的结构。Lindaggrol A（1）是一种未被描述过的重排二元茚，具有前所未有的 3/5/5 三环支架。对所有分离出的化合物进行了检测，以确定它们对 HT-22 细胞中由麦拉宁诱导的铁中毒的神经保护作用。其中，3、12 和 14 具有显著的神经保护活性，EC50 值在 1.4 至 8.7 μM 之间。

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.