Progress and future directions in determining drugs using spectroelectrochemical methods

Vildan Sanko , Ozge Surucu , Filiz Kuralay
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Abstract

The use of drugs is essential for the continuity of human health and the prevention of diseases for living creatures. A key factor in effective drug use is taking it at the correct dosage and timing. Otherwise, some adverse or side effects of these drugs may occur. For this reason, it is crucial to determine the drugs used. In some cases, drug analysis is also essential to understand the use of harmful active substances, such as in the class of prohibited ones. The simple definition of a drug (medication) is a chemical substance that produces a biological effect when adapted to an organism. There are many techniques to determine the drug amount, including spectrometric, chromatographic, electrochemical, colorimetric, or immunological. These analytical techniques have been successfully used to quantify drugs. To improve the effectiveness of the detection protocols, combined systems such as spectroelectrochemistry (SEC) provide significant advantages. This well-known technique unites the principles of spectroscopy and electrochemistry by creating a synergy to provide information on redox properties, mechanisms, and molecular structures. This review highlights the transformative potential of SEC in determining drug molecules, offering a detailed exploration of its principles, methodologies, and unique advantages. The main emphasis, however, is on the use of SEC in pharmaceutical analysis, where its accuracy and adaptability have driven significant progress. Recent studies are presented in detail, demonstrating SEC's effectiveness in detecting, quantifying, and characterizing drug molecules with high sensitivity and specificity.
光谱电化学测定药物的研究进展及未来发展方向
药物的使用对于维持人类健康和预防生物疾病是必不可少的。有效用药的一个关键因素是在正确的剂量和时间服用药物。否则,这些药物可能会产生一些不良或副作用。因此,确定使用的药物是至关重要的。在某些情况下,药物分析对于了解有害活性物质的使用也是必不可少的,例如在违禁物质的类别中。药物(药物)的简单定义是一种化学物质,当适应于生物体时产生生物效应。测定药物量的方法有很多,包括光谱法、色谱法、电化学法、比色法或免疫学法。这些分析技术已成功地用于定量药物。为了提高检测方案的有效性,光谱电化学(SEC)等组合系统提供了显着的优势。这种众所周知的技术通过创造一种协同作用,将光谱学和电化学原理结合起来,提供有关氧化还原性质、机制和分子结构的信息。这篇综述强调了SEC在确定药物分子方面的变革潜力,提供了其原理、方法和独特优势的详细探索。然而,主要的重点是在药物分析中使用SEC,其准确性和适应性已经推动了重大进展。最近的研究详细介绍了SEC在检测、定量和表征药物分子方面的有效性,具有高灵敏度和特异性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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