Total Synthesis and Stereochemical Assignment of Roselipin 1A

Precision Chemistry Pub Date : 2024-12-10 DOI:10.1021/prechem.4c0008210.1021/prechem.4c00082

Yangyang Jiang, Junyang Liu, Yian Guo and Tao Ye*,

引用次数: 0

Abstract

Roselipin 1A, a bioactive natural glycolipid isolated from marine fungal metabolites, presents an unresolved configuration of its nine stereogenic centers within the polyketide chain. Herein, we elucidate the comprehensive stereostructure of roselipin 1A through an integrative approach combining predictive rule-guided analysis with synthetic chemistry. The efficient total synthesis facilitated the unequivocal confirmation of the hypothesized stereochemistry for roselipin 1A, thereby establishing its precise molecular configuration.

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来源期刊

Precision Chemistry 精密化学技术-

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： Chemical research focused on precision enables more controllable predictable and accurate outcomes which in turn drive innovation in measurement science sustainable materials information materials personalized medicines energy environmental science and countless other fields requiring chemical insights.Precision Chemistry provides a unique and highly focused publishing venue for fundamental applied and interdisciplinary research aiming to achieve precision calculation design synthesis manipulation measurement and manufacturing. It is committed to bringing together researchers from across the chemical sciences and the related scientific areas to showcase original research and critical reviews of exceptional quality significance and interest to the broad chemistry and scientific community.