Total Synthesis and Stereochemical Assignment of Roselipin 1A

Precision Chemistry Pub Date : 2024-12-10 DOI:10.1021/prechem.4c0008210.1021/prechem.4c00082

Yangyang Jiang, Junyang Liu, Yian Guo and Tao Ye*,

引用次数: 0

Abstract

Roselipin 1A, a bioactive natural glycolipid isolated from marine fungal metabolites, presents an unresolved configuration of its nine stereogenic centers within the polyketide chain. Herein, we elucidate the comprehensive stereostructure of roselipin 1A through an integrative approach combining predictive rule-guided analysis with synthetic chemistry. The efficient total synthesis facilitated the unequivocal confirmation of the hypothesized stereochemistry for roselipin 1A, thereby establishing its precise molecular configuration.

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玫瑰素1A的全合成及立体化学配位

Roselipin 1A是一种从海洋真菌代谢物中分离出来的具有生物活性的天然糖脂，它在聚酮链中有九个立体中心，其结构尚未确定。在此，我们通过结合预测规则导向分析和合成化学的综合方法阐明了roselipin 1A的综合立体结构。高效的全合成有助于明确确认玫瑰素1A的假设立体化学，从而建立其精确的分子构型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Precision Chemistry 精密化学技术-

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： Chemical research focused on precision enables more controllable predictable and accurate outcomes which in turn drive innovation in measurement science sustainable materials information materials personalized medicines energy environmental science and countless other fields requiring chemical insights.Precision Chemistry provides a unique and highly focused publishing venue for fundamental applied and interdisciplinary research aiming to achieve precision calculation design synthesis manipulation measurement and manufacturing. It is committed to bringing together researchers from across the chemical sciences and the related scientific areas to showcase original research and critical reviews of exceptional quality significance and interest to the broad chemistry and scientific community.