Virulence factors and therapeutic methods of Trueperella pyogenes: A review.

IF 5.5 1区 农林科学 Q1 IMMUNOLOGY
Virulence Pub Date : 2025-12-01 Epub Date: 2025-02-21 DOI:10.1080/21505594.2025.2467161
Xiangfu Wen, Jia Cheng, Mingchao Liu
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引用次数: 0

Abstract

Trueperella pyogenes is a prevalent opportunistic pathogen responsible for a wide range of infections in livestock and wildlife, such as in cattle, pigs, European bison and forest musk deer. Much of the successful infection of T. pyogenes relies on its virulence factors, including pyolysin as well as adhesion factors. The swift rise of bacterial resistance has highlighted the urgent need for developing new therapeutic strategies. Currently, virulence factor-mediated vaccine development and other therapeutic approaches are widely regarded as the primary interventions for addressing diseases associated with this pathogen. This review examines the broader virulence potential of T. pyogenes, focusing on haemolysin, host cell adhesion proteins, the prevalence of antibiotic resistance, and the development of vaccines mediated by virulence factors. Additionally, it discusses current and future approaches aimed at improving therapeutic interventions.

化脓性true eperella的毒力因素及治疗方法综述。
化脓性真菌是一种流行的机会性病原体,可引起牲畜和野生动物的多种感染,如牛、猪、欧洲野牛和森林麝香鹿。化脓性链球菌的成功感染在很大程度上依赖于其毒力因子,包括溶菌酶和粘附因子。细菌抗药性的迅速增加凸显了开发新治疗策略的迫切需要。目前,毒力因子介导的疫苗开发和其他治疗方法被广泛认为是应对该病原体相关疾病的主要干预措施。本综述探讨了化脓性肺结核更广泛的毒力潜力,重点关注溶血素、宿主细胞粘附蛋白、抗生素耐药性的流行以及毒力因子介导的疫苗开发。此外,它还讨论了当前和未来旨在改进治疗干预的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Virulence
Virulence IMMUNOLOGY-MICROBIOLOGY
CiteScore
9.20
自引率
1.90%
发文量
123
审稿时长
6-12 weeks
期刊介绍: Virulence is a fully open access peer-reviewed journal. All articles will (if accepted) be available for anyone to read anywhere, at any time immediately on publication. Virulence is the first international peer-reviewed journal of its kind to focus exclusively on microbial pathogenicity, the infection process and host-pathogen interactions. To address the new infectious challenges, emerging infectious agents and antimicrobial resistance, there is a clear need for interdisciplinary research.
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