From sensory organs to internal pathways: A comprehensive review of amino acid sensing in Drosophila

IF 2.1 3区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Quan Yi, Liangyao Xiong
{"title":"From sensory organs to internal pathways: A comprehensive review of amino acid sensing in Drosophila","authors":"Quan Yi,&nbsp;Liangyao Xiong","doi":"10.1016/j.cbpa.2025.111828","DOIUrl":null,"url":null,"abstract":"<div><div>Organisms require various nutrients to provide energy, support growth, and maintain metabolic balance. Amino acid is among the most basic nutrients, serving as fundamental building blocks for protein synthesis while playing vital roles in growth, development, and reproduction. Understanding the mechanisms by which organisms perceive amino acids is key to unraveling how they select appropriate food sources and adapt to environmental challenges. The fruit fly, <em>Drosophila melanogaster</em>, serves as a powerful model for understanding fundamental genetic and physiological processes. This review focuses on recent advances in amino acid sensing mechanisms in <em>Drosophila melanogaster</em> and their relevance to feeding behavior, nutrient homeostasis, and adaptive responses, and integrates insights into peripheral sensory systems, such as the legs and proboscis, as well as internal regulatory mechanisms within the gut, fat body, and brain. It highlights key molecular players, including ionotropic receptors, gut-derived hormones, neuropeptides, and the microbiome-gut-brain axis. Additionally, the manuscript identifies knowledge gaps and proposes directions for future research, providing a comprehensive overview of this dynamic field.</div></div>","PeriodicalId":55237,"journal":{"name":"Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology","volume":"303 ","pages":"Article 111828"},"PeriodicalIF":2.1000,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1095643325000261","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Organisms require various nutrients to provide energy, support growth, and maintain metabolic balance. Amino acid is among the most basic nutrients, serving as fundamental building blocks for protein synthesis while playing vital roles in growth, development, and reproduction. Understanding the mechanisms by which organisms perceive amino acids is key to unraveling how they select appropriate food sources and adapt to environmental challenges. The fruit fly, Drosophila melanogaster, serves as a powerful model for understanding fundamental genetic and physiological processes. This review focuses on recent advances in amino acid sensing mechanisms in Drosophila melanogaster and their relevance to feeding behavior, nutrient homeostasis, and adaptive responses, and integrates insights into peripheral sensory systems, such as the legs and proboscis, as well as internal regulatory mechanisms within the gut, fat body, and brain. It highlights key molecular players, including ionotropic receptors, gut-derived hormones, neuropeptides, and the microbiome-gut-brain axis. Additionally, the manuscript identifies knowledge gaps and proposes directions for future research, providing a comprehensive overview of this dynamic field.

Abstract Image

从感觉器官到内部通路:果蝇氨基酸传感的全面回顾。
生物体需要各种营养物质来提供能量、支持生长和维持代谢平衡。氨基酸是最基本的营养物质之一,是蛋白质合成的基本组成部分,在生长、发育和繁殖中起着至关重要的作用。了解生物体感知氨基酸的机制是揭示它们如何选择合适的食物来源和适应环境挑战的关键。果蝇(Drosophila melanogaster)是理解基本遗传和生理过程的有力模型。本文综述了黑腹果蝇氨基酸感知机制的最新进展及其与摄食行为、营养稳态和适应性反应的相关性,并整合了对外周感觉系统(如腿和喙)以及肠道、脂肪体和大脑内部调节机制的见解。它强调了关键的分子参与者,包括嗜离子受体、肠道来源的激素、神经肽和微生物群-肠道-脑轴。此外,手稿确定了知识差距,并提出了未来的研究方向,提供了这个动态领域的全面概述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
5.00
自引率
4.30%
发文量
155
审稿时长
3 months
期刊介绍: Part A: Molecular & Integrative Physiology of Comparative Biochemistry and Physiology. This journal covers molecular, cellular, integrative, and ecological physiology. Topics include bioenergetics, circulation, development, excretion, ion regulation, endocrinology, neurobiology, nutrition, respiration, and thermal biology. Study on regulatory mechanisms at any level of organization such as signal transduction and cellular interaction and control of behavior are also published.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信