Aerobic exercise training improves learning and memory performance in hypoxic-exposed rats by activating the hippocampal PKA-CREB-BDNF signaling pathway.

IF 2.3 4区医学 Q3 NEUROSCIENCES

BMC Neuroscience Pub Date : 2025-02-21 DOI:10.1186/s12868-025-00935-x

Shichen Luo, Lei Shi, Tong Liu, Qiguan Jin

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引用次数: 0

Abstract

Background: This study aims to investigate the effects of aerobic exercise training on learning and memory (L&M) performance in rats exposed to altitude hypoxia and its relationship with hippocampal plasticity and the PKA-CREB-BDNF signaling pathway.

Methods: Male Sprague-Dawley rats were exposed to 14.2% hypoxia with or without 60 min of non-weight-bearing swimming training for 8 weeks. The L&M performance was evaluated using the Morris water maze, and the mRNA expression of PSD95, SYP, PKA, CREB, CBP, and BDNF in the hippocampus was detected.

Results: Chronic hypoxia exposure significantly impaired L&M performance and reduced the mRNA expression of hippocampal PSD95, SYP, PKA, CREB, CBP, and BDNF. Aerobic exercise training effectively reversed these changes by enhancing hippocampal synaptic plasticity through the activation of the PKA-CREB-BDNF signaling pathway.

Conclusion: Aerobic exercise training can alleviate the decline in L&M performance caused by altitude hypoxia exposure, possibly through the activation of the hippocampal PKA-CREB-BDNF signaling pathway.

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有氧运动训练通过激活海马PKA-CREB-BDNF信号通路提高缺氧暴露大鼠的学习和记忆表现。

背景：本研究旨在探讨有氧运动训练对高原缺氧大鼠学习记忆能力的影响及其与海马可塑性和PKA-CREB-BDNF信号通路的关系。方法：雄性Sprague-Dawley大鼠在14.2%缺氧条件下，进行或不进行60 min的非负重游泳训练，连续8周。采用Morris水迷宫评价大鼠L&M性能，检测海马组织中PSD95、SYP、PKA、CREB、CBP和BDNF mRNA表达。结果：慢性缺氧暴露显著降低L&M运动能力，降低海马PSD95、SYP、PKA、CREB、CBP和BDNF mRNA表达。有氧运动训练通过激活PKA-CREB-BDNF信号通路，增强海马突触可塑性，有效逆转了这些变化。结论：有氧运动训练可能通过激活海马PKA-CREB-BDNF信号通路，缓解高原缺氧导致的L&M成绩下降。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Neuroscience 医学-神经科学

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

16 months

期刊介绍： BMC Neuroscience is an open access, peer-reviewed journal that considers articles on all aspects of neuroscience, welcoming studies that provide insight into the molecular, cellular, developmental, genetic and genomic, systems, network, cognitive and behavioral aspects of nervous system function in both health and disease. Both experimental and theoretical studies are within scope, as are studies that describe methodological approaches to monitoring or manipulating nervous system function.