Taurine levels and long-term adverse cerebrovascular risk in moyamoya disease: A prognostic perspective study

IF 6.6 2区医学 Q1 NUTRITION & DIETETICS

Clinical nutrition Pub Date : 2025-02-11 DOI:10.1016/j.clnu.2025.02.008

Zhiyao Zheng , Chenglong Liu , Siqi Mou , Junsheng Li , Qiheng He , Wei Liu , Bojian Zhang , Zhikang Zhao , Wei Sun , Qian Zhang , Rong Wang , Yan Zhang , Dong Zhang , Peicong Ge

{"title":"Taurine levels and long-term adverse cerebrovascular risk in moyamoya disease: A prognostic perspective study","authors":"Zhiyao Zheng , Chenglong Liu , Siqi Mou , Junsheng Li , Qiheng He , Wei Liu , Bojian Zhang , Zhikang Zhao , Wei Sun , Qian Zhang , Rong Wang , Yan Zhang , Dong Zhang , Peicong Ge","doi":"10.1016/j.clnu.2025.02.008","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Taurine has been proven to play a significant role in cardiovascular and cerebrovascular diseases, but its relationship with moyamoya disease (MMD) remains unclear. This study aims to investigate the association between serum taurine levels and long-term adverse cerebrovascular events in patients with MMD after revascularization.</div></div><div><h3>Methods</h3><div>This study involved 352 patients with MMD, from whom comprehensive clinical data and blood samples were collected. Serum taurine levels were measured using liquid chromatography-tandem mass spectrometry, and the relationship between serum taurine concentration and various blood indices was evaluated. Cerebrovascular adverse events included transient ischemic attack, ischemic stroke, and hemorrhagic stroke. Taurine, analyzed as a continuous variable, was found to predict a cut-off for postoperative cerebrovascular adverse events in MMD patients at 842.52 μmol/L. The impact of serum taurine levels on the risk of cerebrovascular events was analyzed using Kaplan–Meier (KM) curves, and univariate and multivariate Cox regression analyses were performed to identify predictive factors for postoperative prognosis.</div></div><div><h3>Results</h3><div>Grouping MMD patients by serum taurine levels revealed that higher taurine levels were significantly associated with a lower proportion of hemorrhagic MMD (p = 0.044). Compared with ischemic MMD, patients with hemorrhagic MMD had lower taurine concentrations (p = 0.005). KM curves showed that the incidence of postoperative cerebrovascular adverse events in the high taurine group was significantly lower than in the low taurine group (p = 0.026). Univariate Cox regression analysis indicated that higher taurine concentrations significantly reduced the risk of postoperative cerebrovascular adverse events (Hazard Ratio [HR] = 0.334, 95 % Confidence Interval [CI] = 0.121–0.923, p = 0.035). Furthermore, the multivariate Cox regression model confirmed that taurine level is an independent predictor of long-term adverse cerebrovascular events, with the high concentration group showing a significantly reduced risk.</div></div><div><h3>Conclusions</h3><div>Low serum taurine levels are associated with a higher risk of long-term adverse cerebrovascular events following MMD revascularization. This suggests the significant potential of serum taurine as a prognostic biomarker for postoperative outcomes.</div></div><div><h3>Clinical trial registry number</h3><div>URL: <span><span>https://www.chictr.org.cn/</span><svg><path></path></svg></span>. Unique identifier: ChiCTR2200061889.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"47 ","pages":"Pages 83-93"},"PeriodicalIF":6.6000,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical nutrition","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0261561425000433","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Taurine has been proven to play a significant role in cardiovascular and cerebrovascular diseases, but its relationship with moyamoya disease (MMD) remains unclear. This study aims to investigate the association between serum taurine levels and long-term adverse cerebrovascular events in patients with MMD after revascularization.

Methods

This study involved 352 patients with MMD, from whom comprehensive clinical data and blood samples were collected. Serum taurine levels were measured using liquid chromatography-tandem mass spectrometry, and the relationship between serum taurine concentration and various blood indices was evaluated. Cerebrovascular adverse events included transient ischemic attack, ischemic stroke, and hemorrhagic stroke. Taurine, analyzed as a continuous variable, was found to predict a cut-off for postoperative cerebrovascular adverse events in MMD patients at 842.52 μmol/L. The impact of serum taurine levels on the risk of cerebrovascular events was analyzed using Kaplan–Meier (KM) curves, and univariate and multivariate Cox regression analyses were performed to identify predictive factors for postoperative prognosis.

Results

Grouping MMD patients by serum taurine levels revealed that higher taurine levels were significantly associated with a lower proportion of hemorrhagic MMD (p = 0.044). Compared with ischemic MMD, patients with hemorrhagic MMD had lower taurine concentrations (p = 0.005). KM curves showed that the incidence of postoperative cerebrovascular adverse events in the high taurine group was significantly lower than in the low taurine group (p = 0.026). Univariate Cox regression analysis indicated that higher taurine concentrations significantly reduced the risk of postoperative cerebrovascular adverse events (Hazard Ratio [HR] = 0.334, 95 % Confidence Interval [CI] = 0.121–0.923, p = 0.035). Furthermore, the multivariate Cox regression model confirmed that taurine level is an independent predictor of long-term adverse cerebrovascular events, with the high concentration group showing a significantly reduced risk.

Conclusions

Low serum taurine levels are associated with a higher risk of long-term adverse cerebrovascular events following MMD revascularization. This suggests the significant potential of serum taurine as a prognostic biomarker for postoperative outcomes.

Clinical trial registry number

URL: https://www.chictr.org.cn/. Unique identifier: ChiCTR2200061889.

查看原文本刊更多论文

烟雾病患者的牛磺酸水平与长期不良脑血管风险：一项预后研究

牛磺酸已被证明在心脑血管疾病中发挥重要作用，但其与烟雾病（MMD）的关系尚不清楚。本研究旨在探讨烟雾病患者血运重建术后血清牛磺酸水平与长期不良脑血管事件的关系。方法收集352例烟雾病患者的临床资料和血液样本。采用液相色谱-串联质谱法测定血清牛磺酸水平，并评价血清牛磺酸浓度与各项血液指标的关系。脑血管不良事件包括短暂性脑缺血发作、缺血性脑卒中和出血性脑卒中。牛磺酸作为一个连续变量进行分析，发现在842.52 μmol/L时可以预测烟雾病患者术后脑血管不良事件的截止值。采用Kaplan-Meier （KM）曲线分析血清牛磺酸水平对脑血管事件发生风险的影响，并进行单因素和多因素Cox回归分析，确定影响术后预后的预测因素。结果根据血清牛磺酸水平对烟雾病患者进行分组发现，较高的牛磺酸水平与较低的出血性烟雾病患者比例显著相关（p = 0.044）。与缺血性烟雾病患者相比，出血性烟雾病患者的牛磺酸浓度较低（p = 0.005）。KM曲线显示，高牛磺酸组术后脑血管不良事件发生率明显低于低牛磺酸组（p = 0.026）。单因素Cox回归分析显示，较高的牛磺酸浓度可显著降低术后脑血管不良事件的发生风险（风险比[HR] = 0.334, 95%可信区间[CI] = 0.121 ~ 0.923, p = 0.035）。此外，多变量Cox回归模型证实牛磺酸水平是长期脑血管不良事件的独立预测因子，高浓度组的风险显著降低。结论低血清牛磺酸水平与烟雾病血运重建术后长期不良脑血管事件的高风险相关。这表明血清牛磺酸作为术后预后的生物标志物具有重要的潜力。临床试验注册编号url: https://www.chictr.org.cn/。唯一标识符：ChiCTR2200061889。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical nutrition 医学-营养学

CiteScore

14.10

自引率

6.30%

发文量

356

审稿时长

28 days

期刊介绍： Clinical Nutrition, the official journal of ESPEN, The European Society for Clinical Nutrition and Metabolism, is an international journal providing essential scientific information on nutritional and metabolic care and the relationship between nutrition and disease both in the setting of basic science and clinical practice. Published bi-monthly, each issue combines original articles and reviews providing an invaluable reference for any specialist concerned with these fields.