Neuropsychology of Alzheimer's disease: From preclinical phase to dementia.

IF 1.4 4区 心理学 Q4 CLINICAL NEUROLOGY
Ezgi Soncu Büyükişcan
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引用次数: 0

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by significant cognitive and functional decline, initially presenting with episodic memory impairment. A thorough neuropsychological assessment is essential for AD diagnosis, particularly in the early stages in which interventions may be more effective. This paper reviews the neuropsychology of Alzheimer's disease, highlighting the cognitive progression of the disease. In the typical forms of AD, episodic memory appears to be the first and foremost affected cognitive domain. As AD progresses, cognitive impairments extend beyond memory to affect various domains such as attention, executive functions, language, and visuospatial abilities. Neuropsychiatric issues, such as depression and anxiety, which often accompany cognitive decline, are also common, especially at the advanced stages of the disease. While episodic memory impairment is the earliest and most prominent feature in typical AD cases, comprehensive assessments, including social cognition and neuropsychiatric evaluations, are crucial for accurate diagnosis and treatment planning.

阿尔茨海默病的神经心理学:从临床前阶段到痴呆。
阿尔茨海默病(AD)是一种进行性神经退行性疾病,其特征是显著的认知和功能下降,最初表现为情景记忆障碍。彻底的神经心理学评估对阿尔茨海默病的诊断至关重要,特别是在早期阶段,干预可能更有效。本文综述了阿尔茨海默病的神经心理学,重点介绍了该疾病的认知进展。在典型的阿尔茨海默病中,情景记忆似乎是最先受到影响的认知领域。随着阿尔茨海默病的进展,认知障碍会扩展到记忆以外的各个领域,如注意力、执行功能、语言和视觉空间能力。神经精神问题,如抑郁和焦虑,往往伴随着认知能力下降,也很常见,特别是在疾病的晚期。虽然情景记忆障碍是典型AD病例中最早和最突出的特征,但综合评估,包括社会认知和神经精神评估,对于准确诊断和治疗计划至关重要。
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来源期刊
Applied Neuropsychology-Adult
Applied Neuropsychology-Adult CLINICAL NEUROLOGY-PSYCHOLOGY
CiteScore
4.50
自引率
11.80%
发文量
134
期刊介绍: pplied Neuropsychology-Adult publishes clinical neuropsychological articles concerning assessment, brain functioning and neuroimaging, neuropsychological treatment, and rehabilitation in adults. Full-length articles and brief communications are included. Case studies of adult patients carefully assessing the nature, course, or treatment of clinical neuropsychological dysfunctions in the context of scientific literature, are suitable. Review manuscripts addressing critical issues are encouraged. Preference is given to papers of clinical relevance to others in the field. All submitted manuscripts are subject to initial appraisal by the Editor-in-Chief, and, if found suitable for further considerations are peer reviewed by independent, anonymous expert referees. All peer review is single-blind and submission is online via ScholarOne Manuscripts.
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