Autonomic Disequilibrium at Rest in Autistic Children and Adults.

IF 2.2 3区心理学 Q2 PSYCHOLOGY, CLINICAL

Applied Psychophysiology and Biofeedback Pub Date : 2025-02-21 DOI:10.1007/s10484-025-09696-z

Maria Rosa Bufo, Marco Guidotti, Mathieu Lemaire, Joëlle Malvy, Emmanuelle Houy-Durand, Frédérique Bonnet-Brilhault, Frédéric Briend, Nadia Aguillon-Hernandez, Claire Wardak

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Abstract

Autism Spectrum Disorder (ASD) symptoms have been proposed to be linked to Autonomic Nervous System (ANS) atypical functioning, in particular sympathetic hyper-arousal and parasympathetic under-activation. The objective of this study was to characterize autonomic functioning at rest in autistic and neurotypical children and adults. To characterize several aspects of autonomic functioning, we recorded simultaneously pupil diameter, heart rate and electrodermal activity during 5 min of rest in 44 children (6-12 years old, 22 autistic) and 42 adults (19-52 years old, 21 autistic). Several parameters allowed to characterize tonic and phasic indices of sympathetic and parasympathetic systems at rest. Autistic children exhibited the expected pattern of parasympathetic under-activation at rest compared to their typically developing (TD) peers, and with a tendency for a higher phasic sympathetic activity. Adults exhibited a reverse autonomic pattern, with autistic individuals showing higher sympathetic tonus and lower sympathetic phasic activity than their TD peers. In conclusion, we observed an autonomic disequilibrium at rest both in autistic children and adults, but with opposite patterns that could reflect adaptive compensation mechanisms during maturation. This disequilibrium in autistic children would switch from excessive phasic components to excessive tonic components in adults, possibly subtended by an atypical locus coeruleus functioning.

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来源期刊

Applied Psychophysiology and Biofeedback PSYCHOLOGY, CLINICAL-

CiteScore

5.30

自引率

13.30%

发文量

期刊介绍： Applied Psychophysiology and Biofeedback is an international, interdisciplinary journal devoted to study of the interrelationship of physiological systems, cognition, social and environmental parameters, and health. Priority is given to original research, basic and applied, which contributes to the theory, practice, and evaluation of applied psychophysiology and biofeedback. Submissions are also welcomed for consideration in several additional sections that appear in the journal. They consist of conceptual and theoretical articles; evaluative reviews; the Clinical Forum, which includes separate categories for innovative case studies, clinical replication series, extended treatment protocols, and clinical notes and observations; the Discussion Forum, which includes a series of papers centered around a topic of importance to the field; Innovations in Instrumentation; Letters to the Editor, commenting on issues raised in articles previously published in the journal; and select book reviews. Applied Psychophysiology and Biofeedback is the official publication of the Association for Applied Psychophysiology and Biofeedback.