Autonomic Disequilibrium at Rest in Autistic Children and Adults.

IF 2.2 3区心理学 Q2 PSYCHOLOGY, CLINICAL

Applied Psychophysiology and Biofeedback Pub Date : 2025-02-21 DOI:10.1007/s10484-025-09696-z

Maria Rosa Bufo, Marco Guidotti, Mathieu Lemaire, Joëlle Malvy, Emmanuelle Houy-Durand, Frédérique Bonnet-Brilhault, Frédéric Briend, Nadia Aguillon-Hernandez, Claire Wardak

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Abstract

Autism Spectrum Disorder (ASD) symptoms have been proposed to be linked to Autonomic Nervous System (ANS) atypical functioning, in particular sympathetic hyper-arousal and parasympathetic under-activation. The objective of this study was to characterize autonomic functioning at rest in autistic and neurotypical children and adults. To characterize several aspects of autonomic functioning, we recorded simultaneously pupil diameter, heart rate and electrodermal activity during 5 min of rest in 44 children (6-12 years old, 22 autistic) and 42 adults (19-52 years old, 21 autistic). Several parameters allowed to characterize tonic and phasic indices of sympathetic and parasympathetic systems at rest. Autistic children exhibited the expected pattern of parasympathetic under-activation at rest compared to their typically developing (TD) peers, and with a tendency for a higher phasic sympathetic activity. Adults exhibited a reverse autonomic pattern, with autistic individuals showing higher sympathetic tonus and lower sympathetic phasic activity than their TD peers. In conclusion, we observed an autonomic disequilibrium at rest both in autistic children and adults, but with opposite patterns that could reflect adaptive compensation mechanisms during maturation. This disequilibrium in autistic children would switch from excessive phasic components to excessive tonic components in adults, possibly subtended by an atypical locus coeruleus functioning.

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自闭症儿童和成人休息时的自主神经失衡。

自闭症谱系障碍（ASD）症状被认为与自主神经系统（ANS）非典型功能有关，特别是交感神经过度觉醒和副交感神经激活不足。本研究的目的是表征自闭症和神经正常的儿童和成人休息时的自主神经功能。为了描述自主神经功能的几个方面，我们同时记录了44名儿童（6-12岁，22名自闭症患者）和42名成人（19-52岁，21名自闭症患者）在5分钟休息时的瞳孔直径、心率和皮电活动。几个参数允许表征在休息时交感和副交感系统的张力和相位指数。与正常发育的同龄人相比，自闭症儿童在休息时表现出预期的副交感神经激活不足的模式，并且有更高的相交感神经活动的趋势。成年人表现出相反的自主神经模式，自闭症个体比TD同龄人表现出更高的交感张力和更低的交感相活动。总之，我们观察到自闭症儿童和成人在休息时都存在自主神经失衡，但其模式相反，可以反映成熟过程中的适应性补偿机制。自闭症儿童的这种不平衡在成人中会从过度的相位成分转变为过度的强直性成分，可能伴随着非典型的蓝斑功能。

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来源期刊

Applied Psychophysiology and Biofeedback PSYCHOLOGY, CLINICAL-

CiteScore

5.30

自引率

13.30%

发文量

期刊介绍： Applied Psychophysiology and Biofeedback is an international, interdisciplinary journal devoted to study of the interrelationship of physiological systems, cognition, social and environmental parameters, and health. Priority is given to original research, basic and applied, which contributes to the theory, practice, and evaluation of applied psychophysiology and biofeedback. Submissions are also welcomed for consideration in several additional sections that appear in the journal. They consist of conceptual and theoretical articles; evaluative reviews; the Clinical Forum, which includes separate categories for innovative case studies, clinical replication series, extended treatment protocols, and clinical notes and observations; the Discussion Forum, which includes a series of papers centered around a topic of importance to the field; Innovations in Instrumentation; Letters to the Editor, commenting on issues raised in articles previously published in the journal; and select book reviews. Applied Psychophysiology and Biofeedback is the official publication of the Association for Applied Psychophysiology and Biofeedback.