Therapeutic efficacy of moxifloxacin and marbofloxacin against mastitis in buffalo.

Abstract

Mastitis is a common economically important disease of dairy buffaloes. Antibiotic resistance is the most cited reason behind the failure of clinical mastitis treatment in buffaloes. Selection of antibiotic after antibiotic sensitivity test is the key to avoid multidrug resistance (MDR) for mastitis therapy. Therefore, the present research work was carried out to evaluate efficacy of moxifloxacin and marbofloxacin in clinical mastitis in buffaloes based on the sensitivity against common mastitic bacteria in buffaloes. Total twenty clinical mastitis positive buffaloes were selected after screening of 129 lactating buffaloes by strip cup test and clinical signs, in and around Parbhani area. The selected buffaloes were divided into 2 groups, 10 animals in each. Group I was treated with injection Moxifloxacin @ 5 mg/kg BW IM for 5 days and group II received injection Marbofloxacin @ 2 mg/kg BW IM for 5 days. Supportive treatment was given in both groups as antihistaminic, multivitamins and NSAIDs. The clinical parameters like rectal temperature, heart rate and respiratory rate showed significant improvement in both the treatment groups. Haematolgical study showed significant improvement in TLC, neutrophil and lymphocyte count while apparent but non-significant improvement observed in Hb, PCV, basophil, eosinophil and monocyte count. The most frequent bacteria observed in mastitic samples were Staphylococcus aureus, followed by E. coli, Klesiella spp. and mixed bacterial infection. Marbofloxacin showed highest sensitivity to mastitis causing bacteria followed by Moxifloxacin, Enrofloxacin and Ciprofloxacin. The comparative efficacies in treatment groups were calculated on the basis of improvement in clinical signs, strip cup test and somatic cell count after treatment. Higher efficacy of Marbofloxacin was found (70%) as compared to Moxifloxacin (50%) for treatment of clinical mastitis. Hence, concluded that marbofloxacin could be appropriative antibiotic agent in the treatment of mastitis in buffalo.