Nourhan G Naga, Habiba M Magdy, Sally Negm, Attalla F El-Kott, Mohammed A AlShehri, Mohammad M El-Metwally, Sahar E Abo-Neima, Emad M Elsehly
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引用次数: 0
Abstract
Biofilm is a powerful barrier that significantly enhances the pathogenicity of bacteria and the development of multidrug resistance. Nanoparticles (NPs) coupled with biomolecules provide a novel approach to addressing this issue. This review briefly discusses the current trends in Biomolecule-Conjugated NPs combined with enzymes, antibiotics, biosurfactants, and natural bioactive compounds as antibiofilm agents emphasizing their superior antibiofilm activity. This conjugation enhances bioavailability, lowers toxicity, requires smaller dosage, and reduces complications caused by infections associated with biofilms. These conjugated systems offer an avenue for industrial, ecological, and medical applications. By increasing the variety of these conjugation techniques, innovative approaches to biofilm-related problems will become possible, with significant advantages for healthcare and other fields.
期刊介绍：
Microbial Pathogenesis publishes original contributions and reviews about the molecular and cellular mechanisms of infectious diseases. It covers microbiology, host-pathogen interaction and immunology related to infectious agents, including bacteria, fungi, viruses and protozoa. It also accepts papers in the field of clinical microbiology, with the exception of case reports.
Research Areas Include:
-Pathogenesis
-Virulence factors
-Host susceptibility or resistance
-Immune mechanisms
-Identification, cloning and sequencing of relevant genes
-Genetic studies
-Viruses, prokaryotic organisms and protozoa
-Microbiota
-Systems biology related to infectious diseases
-Targets for vaccine design (pre-clinical studies)
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