The people behind the papers - Laura Aviñó-Esteban and James Sharpe.

IF 3.7 2区生物学 Q1 DEVELOPMENTAL BIOLOGY

Development Pub Date : 2025-02-15 Epub Date: 2025-02-21 DOI:10.1242/dev.204707

引用次数: 0

Abstract

It can be challenging to understand the dynamics of gene expression patterns when embryos develop inside a uterus, making it impossible to image changes to gene expression in real time. A new paper in Development presents a pipeline where images of mouse embryos at discrete developmental timepoints can be used to reconstruct a continuous description of gene expression changes over time. To learn more about the story behind the paper, we caught up with first author Laura Aviñó-Esteban and corresponding author James Sharpe, Head of EMBL Barcelona, Spain.

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这些报纸背后的人——劳拉Aviñó-Esteban和詹姆斯夏普。

当胚胎在子宫内发育时，要了解基因表达模式的动态变化具有挑战性，因为不可能对基因表达的变化进行实时成像。发育》（Development）杂志上的一篇新论文提出了一种方法，可以利用小鼠胚胎在离散发育时间点的图像重建基因表达随时间变化的连续描述。为了进一步了解论文背后的故事，我们采访了论文的第一作者劳拉-阿维诺-埃斯特班（Laura Aviñó-Esteban）和通讯作者、西班牙巴塞罗那 EMBL 实验室主任詹姆斯-夏普（James Sharpe）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Development 生物-发育生物学

CiteScore

6.70

自引率

4.30%

发文量

433

审稿时长

3 months

期刊介绍： Development’s scope covers all aspects of plant and animal development, including stem cell biology and regeneration. The single most important criterion for acceptance in Development is scientific excellence. Research papers (articles and reports) should therefore pose and test a significant hypothesis or address a significant question, and should provide novel perspectives that advance our understanding of development. We also encourage submission of papers that use computational methods or mathematical models to obtain significant new insights into developmental biology topics. Manuscripts that are descriptive in nature will be considered only when they lay important groundwork for a field and/or provide novel resources for understanding developmental processes of broad interest to the community. Development includes a Techniques and Resources section for the publication of new methods, datasets, and other types of resources. Papers describing new techniques should include a proof-of-principle demonstration that the technique is valuable to the developmental biology community; they need not include in-depth follow-up analysis. The technique must be described in sufficient detail to be easily replicated by other investigators. Development will also consider protocol-type papers of exceptional interest to the community. We welcome submission of Resource papers, for example those reporting new databases, systems-level datasets, or genetic resources of major value to the developmental biology community. For all papers, the data or resource described must be made available to the community with minimal restrictions upon publication. To aid navigability, Development has dedicated sections of the journal to stem cells & regeneration and to human development. The criteria for acceptance into these sections is identical to those outlined above. Authors and editors are encouraged to nominate appropriate manuscripts for inclusion in one of these sections.