Effect of Polyphenol Supplementation on Adiposity: A Systematic Review of Randomized Clinical Trials.

IF 5.5 3区医学 Q1 NUTRITION & DIETETICS

Current Nutrition Reports Pub Date : 2025-02-21 DOI:10.1007/s13668-025-00626-3

Isabella Mendes, Madalena Geralda Cupertino Ribeiro, Layla Fagundes de Souza, Carla de Oliveira Barbosa Rosa, Helen Hermana Miranda Hermsdorff, Josefina Bressan

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Abstract

Purpose of review: The obesity is a multifactorial disease, result of high adiposity and excessive body fat, with closed relation to the development of other chronic disease. The growing obesity-related costs has relevant public health impact. In turn, the polyphenol is a dietary bioactive compound with recognized antioxidant propriety and healthy benefits. The polyphenol supplementation can be a promising strategy for obesity treatment, due to its potential antiadipogenic and metabolic control effects, improving quality of life of this population. This systematic review evaluated the effect of polyphenol supplementation on adiposity in overweight adults and elderly people (Systematic Review Registration: CRD42024586193).

Recent findings: Current research demonstrates that polyphenol supplementation resulted in a significant decrease in markers of central adiposity (percentage of body fat, fat mass, waist circumference) and visceral adiposity (visceral adipose tissue). The mechanisms may be involved in the activation of lipid turnover pathways, AMPK activation and suppression of transcription factors (SREBPs, PPAR-γ and C/EBP-α) and key enzymes in lipid synthesis in adipose tissue. Furthermore, polyphenol supplementation has also beneficial effects on controlling of blood pressure, blood glucose and lipid profile, contribute to the prevention of other chronic metabolic disorders. Adiposity refers to the distribution of body fat, closely related to cardiometabolic risk, while polyphenols are phytochemicals with potential health-promoting effects. However, the role of these bioactive compounds in controlling adiposity is not well established. This systematic review presents antiadipogenic and metabolic control effects of the dietary polyphenol supplementation. However, there is no consensus on a specific dosage or form of presentation that generates the best results. Further studies are needed to elucidate better the potential effect of these compounds and related-pathway, to perform clinical validation of their use, and to establish the benefits of their long-term use.

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多酚补充剂对肥胖的影响：一项随机临床试验的系统综述。

综述目的：肥胖是一种多因素疾病，是高脂肪和体脂过多的结果，与其他慢性疾病的发展密切相关。日益增长的肥胖相关成本对公共卫生产生了相关影响。反过来，多酚是一种膳食生物活性化合物，具有公认的抗氧化性和健康益处。由于其潜在的抗脂肪和代谢控制作用，多酚补充剂可以改善这一人群的生活质量，因此可以成为一种有前途的肥胖治疗策略。本系统综述评估了多酚补充剂对超重成人和老年人肥胖的影响（系统综述注册号：CRD42024586193）。最新发现：目前的研究表明，补充多酚可以显著降低中心性肥胖（体脂百分比、脂肪量、腰围）和内脏脂肪（内脏脂肪组织）的标志物。其机制可能涉及脂肪组织中脂质转化途径的激活、AMPK的激活以及转录因子（SREBPs、PPAR-γ和C/EBP-α）和脂质合成关键酶的抑制。此外，多酚补充对控制血压、血糖和血脂也有有益作用，有助于预防其他慢性代谢疾病。肥胖是指身体脂肪的分布，与心脏代谢风险密切相关，而多酚是具有潜在健康促进作用的植物化学物质。然而，这些生物活性化合物在控制肥胖方面的作用尚未得到很好的证实。本文综述了膳食中多酚的抗脂肪和代谢控制作用。然而，对于产生最佳效果的具体剂量或呈现形式尚无共识。需要进一步的研究来更好地阐明这些化合物及其相关途径的潜在作用，对其使用进行临床验证，并确定其长期使用的益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Nutrition Reports Agricultural and Biological Sciences-Food Science

CiteScore

7.70

自引率

2.00%

发文量

期刊介绍： This journal aims to provide comprehensive review articles that emphasize significant developments in nutrition research emerging in recent publications. By presenting clear, insightful, balanced contributions by international experts, the journal intends to discuss the influence of nutrition on major health conditions such as diabetes, cardiovascular disease, cancer, and obesity, as well as the impact of nutrition on genetics, metabolic function, and public health. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 25 internationally diverse members reviews the annual table of contents, suggests topics of special importance to their country/region, and ensures that topics and current and include emerging research.