The Allelic and Phenotypic Frequencies of the ABO and Rh Blood Types in Pregnant Women in Addis Ababa, Ethiopia.

IF 2.6 3区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BioMed Research International Pub Date : 2025-02-13 eCollection Date: 2025-01-01 DOI:10.1155/bmri/8649988
Mekdes Wondiye Tedbabe, Dagim Jirata Birri, Takele Taye Desta
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Abstract

Background: ABO-rhesus (Rh) blood testing screens blood types according to the antigenic properties of red blood cells. Objective: This study reports the allelic and phenotypic frequency distribution of the ABO and Rh blood groups in pregnant women who attended antenatal care (ANC) at Zewditu Memorial Hospital in Addis Ababa, Ethiopia, and the likelihood for the occurrence of erythroblastosis fetalis (E. fetalis). Methods: A retrospective study was conducted on pregnant women who attended ANC from 2015 to 2019 and typed for ABO and Rh blood groups. The Hardy-Weinberg equilibrium was used to determine the allelic frequency of ABO and Rh blood types. The likelihood of the occurrence of E. fetalis was computed. Results: Among the 2453 women who had been admitted to ANC, 2407 (98.1%) pregnant women who had been typed for the ABO and Rh blood groups were included in this retrospective study. We found that Type O blood was the most common one (38.9%), while Types A (31.3%), B (23.8%), and AB (6.0%) blood were scored with modest to lower proportions. Among blood group-typed women, 94.2% were Rh-positive. The allelic frequency of O was 0.62, whereas A (0.22) and B (0.16) had modest proportions. The allelic frequency of D was 0.76 and d was 0.24. The likelihood of the occurrence of E. fetalis was 5%. Our findings show that both the ABO (χ-squared = 6.1439, df = 3, pvalue = 0.1048) and the Rh (χ-squared = 0.000103, df = 1, pvalue = 0.9919) blood groups were segregated at the Hardy-Weinberg proportions. Studies need to investigate the evolutionary forces that have made the ABO and Rh blood types segregate at the Hardy-Weinberg proportion.

埃塞俄比亚亚的斯亚贝巴孕妇ABO和Rh血型的等位基因和表型频率
背景:abo -恒河(Rh)血液检测根据红细胞的抗原特性筛选血型。目的:本研究报告了在埃塞俄比亚亚的斯亚贝巴Zewditu纪念医院接受产前护理(ANC)的孕妇ABO和Rh血型的等位基因和表型频率分布,以及胎儿成红细胞增多症(E. fetalis)发生的可能性。方法:对2015 - 2019年参加非国大的孕妇进行回顾性研究,并对ABO和Rh血型进行分型。Hardy-Weinberg平衡用于测定ABO和Rh血型的等位基因频率。计算发生e型胎儿的可能性。结果:在2453例ANC住院妇女中,2407例(98.1%)经ABO和Rh血型分型的孕妇被纳入回顾性研究。我们发现O型血是最常见的血型(38.9%),而A型血(31.3%),B型血(23.8%)和AB型血(6.0%)的比例中等至较低。血型女性中rh阳性占94.2%。O的等位基因频率为0.62,而A(0.22)和B(0.16)的比例中等。D的等位基因频率为0.76,D为0.24。发生e型胎儿的可能性为5%。结果表明,ABO血型(χ-squared = 6.1439, df = 3, p值= 0.1048)和Rh血型(χ-squared = 0.000103, df = 1, p值= 0.9919)均按Hardy-Weinberg比例分离。研究需要调查使ABO血型和Rh血型按Hardy-Weinberg比例分离的进化力量。
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来源期刊
BioMed Research International
BioMed Research International BIOTECHNOLOGY & APPLIED MICROBIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
6.70
自引率
0.00%
发文量
1942
审稿时长
19 weeks
期刊介绍: BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
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