Development of amide-based molecular cages for the highly selective and sensitive detection of nicotine†

IF 2.7 3区 化学 Q2 CHEMISTRY, ANALYTICAL
Mina Bagherifard, Amrit Kaur, Kamal E. S. Nassar, Neelam Tariq, Zois Syrgiannis and Ioannis Spanopoulos
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引用次数: 0

Abstract

Nicotine is a harmful sympathomimetic drug associated with serious health issues. Herein, a novel amide-based bistren-type cage, BiP-Am, has been developed for the selective fluorescence-based sensing of nicotine in human urine samples and cigarettes. The corresponding detection limit features a value of 0.4 nM, among the best reported in the literature. Selectivity experiments demonstrate that BiP-Am can efficiently detect nicotine in the presence of multiple interfering analytes such as sodium, potassium, urea and uric acid. A plausible mechanism has been proposed herein, revealing that nicotine is showing an inner-filter effect quenching the BiP-Am fluorescence emission. Our strategy poses a facile and versatile method for nicotine detection in portable applications.

Abstract Image

高选择性、高灵敏度检测尼古丁的酰胺基分子笼的研制。
尼古丁是一种有害的拟交感神经药物,与严重的健康问题有关。在此,一种新型的酰胺基bitron型笼,BiP-Am,已经被开发出来,用于选择性荧光检测人类尿液样本和香烟中的尼古丁。相应的检出限为0.4 nM,是文献报道的最佳检出限之一。选择性实验表明,在钠、钾、尿素、尿酸等多种干扰物存在的情况下,BiP-Am能有效检测尼古丁。本文提出了一种合理的机制,表明尼古丁表现出内部过滤效应,猝灭BiP-Am荧光发射。我们的策略为便携式应用中的尼古丁检测提供了一种简便而通用的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Analytical Methods
Analytical Methods CHEMISTRY, ANALYTICAL-FOOD SCIENCE & TECHNOLOGY
CiteScore
5.10
自引率
3.20%
发文量
569
审稿时长
1.8 months
期刊介绍: Early applied demonstrations of new analytical methods with clear societal impact
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