Development of amide-based molecular cages for the highly selective and sensitive detection of nicotine†

IF 2.7 3区 化学 Q2 CHEMISTRY, ANALYTICAL
Mina Bagherifard, Amrit Kaur, Kamal E. S. Nassar, Neelam Tariq, Zois Syrgiannis and Ioannis Spanopoulos
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引用次数: 0

Abstract

Nicotine is a harmful sympathomimetic drug associated with serious health issues. Herein, a novel amide-based bistren-type cage, BiP-Am, has been developed for the selective fluorescence-based sensing of nicotine in human urine samples and cigarettes. The corresponding detection limit features a value of 0.4 nM, among the best reported in the literature. Selectivity experiments demonstrate that BiP-Am can efficiently detect nicotine in the presence of multiple interfering analytes such as sodium, potassium, urea and uric acid. A plausible mechanism has been proposed herein, revealing that nicotine is showing an inner-filter effect quenching the BiP-Am fluorescence emission. Our strategy poses a facile and versatile method for nicotine detection in portable applications.

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来源期刊
Analytical Methods
Analytical Methods CHEMISTRY, ANALYTICAL-FOOD SCIENCE & TECHNOLOGY
CiteScore
5.10
自引率
3.20%
发文量
569
审稿时长
1.8 months
期刊介绍: Early applied demonstrations of new analytical methods with clear societal impact
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