Relation Between Brain Morphological Features and Psychiatric Hospitalization Risk in Major Depressive and Bipolar Disorders.

IF 5.3 2区 医学 Q1 PSYCHIATRY
Kamilla W Miskowiak, Julian Macoveanu, Brice Ozenne, Emily E Beaman, Vibeke H Dam, Patrick M Fisher, Gitte M Knudsen, Lars V Kessing, Martin B Jørgensen, Vibe G Frokjaer, Anjali Sankar
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引用次数: 0

Abstract

Introduction: Patients with mood disorders, especially, major depressive disorder (MDD) and bipolar disorder (BD), are at heightened risk of relapse and psychiatric rehospitalizations. Therefore, there is an urgent need to identify modifiable biomarkers to inform personalized and intensified prevention strategies for those at the greatest risk of relapse and hospital readmissions. Brain structural measures subserving cognitive function hold particular promise among potential predictive biomarkers.

Methods: In the present study, structural magnetic resonance imaging scans were obtained from 319 patients with MDD (n = 241) or BD (n = 78). Longitudinal data on psychiatric hospitalization for up to 10 years were available from the Danish National population-based registers. Interhemispheric hippocampal asymmetry, a putative marker of cognitive function and brain reserve, was calculated for each patient. The association between hippocampal asymmetry and future psychiatric hospitalization was assessed using a cause-specific Cox regression model. Exploratory analyses, also using a cause-specific Cox model, assessed the association of prefrontal and hippocampal gray matter volume and whole-brain white matter volume with hospitalizations.

Results: The results indicated a negative association between rightward hippocampal asymmetry (i.e., left

Conclusion: The findings suggest a role for hippocampal and, additionally, prefrontal morphological features in the risk of future psychiatric hospitalizations in mood disorders.

重度抑郁和双相情感障碍患者脑形态特征与精神住院风险的关系
心境障碍患者,特别是重度抑郁障碍(MDD)和双相情感障碍(BD)患者复发和再住院的风险较高。因此,迫切需要确定可修改的生物标志物,为复发和再入院风险最高的患者提供个性化和强化的预防策略。服务于认知功能的脑结构测量在潜在的预测性生物标志物中具有特别的前景。方法:本研究对319例MDD (n = 241)或BD (n = 78)患者进行结构磁共振成像扫描。长达10年的精神病住院的纵向数据可从丹麦国家人口登记中获得。计算每个患者的海马半球间不对称性,这是认知功能和脑储备的一个假定标志。使用病因特异性Cox回归模型评估海马不对称与未来精神病住院之间的关系。探索性分析也使用了病因特异性Cox模型,评估了前额叶和海马灰质体积以及全脑白质体积与住院治疗的关系。结果:结果表明,海马向右不对称(即左侧)之间存在负相关。结论:研究结果表明,海马以及前额叶形态学特征在情绪障碍患者未来精神住院的风险中起着重要作用。
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来源期刊
Acta Psychiatrica Scandinavica
Acta Psychiatrica Scandinavica 医学-精神病学
CiteScore
11.20
自引率
3.00%
发文量
135
审稿时长
6-12 weeks
期刊介绍: Acta Psychiatrica Scandinavica acts as an international forum for the dissemination of information advancing the science and practice of psychiatry. In particular we focus on communicating frontline research to clinical psychiatrists and psychiatric researchers. Acta Psychiatrica Scandinavica has traditionally been and remains a journal focusing predominantly on clinical psychiatry, but translational psychiatry is a topic of growing importance to our readers. Therefore, the journal welcomes submission of manuscripts based on both clinical- and more translational (e.g. preclinical and epidemiological) research. When preparing manuscripts based on translational studies for submission to Acta Psychiatrica Scandinavica, the authors should place emphasis on the clinical significance of the research question and the findings. Manuscripts based solely on preclinical research (e.g. animal models) are normally not considered for publication in the Journal.
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