Statistical Multiscore Functional Atlas Creation for Image-Guided Deep Brain Stimulation

Abstract

Deep brain stimulation is increasingly performed for patients who suffer from drug-resistant movement disorders. It still remains challenging to determine the optimal electrode contact location to obtain the optimal surgical outcome and simultaneously minimize adverse effects. This paper proposes to construct a new statistical functional atlas to guide electrode contact targeting during deep brain stimulation. The construction of the atlas consists of four main steps: 1) multimodal image segmentation and registration, 2) activation volume modeling, 3) computing and combining multiple functional scores, and 4) generation of multiscore functional atlas. Based on these steps, the statistical functional atlas is created by integrating anatomical information analysis with multiple clinical scores that postoperatively characterize stimulation efficacy (e.g., motor symptom) and adverse effect. We evaluated the created atlas on 40 subthalamic nucleus stimulated parkinsonian patient datasets. The experimental results show that the reproducibility of the created statistical functional atlas was more than 75% in the cross validation. In addition, the motor, neuropsychological, and health scores can be reproduced up to 77%, 82%, and 78%. Compared to the actually implanted electrode position, the atlas predicted and the manually planned electrode position errors were 2.89 mm and 2.38 mm, respectively. The constructed multiscore atlas provides an automatic and accurate electrode targeting strategy that potentially outperforms manually planned approaches.