Hippocampal sclerosis in senile dementia of the neurofibrillary tangle type

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Journal of the Neurological Sciences Pub Date : 2025-02-20 DOI:10.1016/j.jns.2025.123437

Nao Tahara , Daisuke Tahara , Akio Akagi , Yuichi Riku , Jun Sone , Hiroaki Miyahara , Atsushi Nagai , Mari Yoshida , Yasushi Iwasaki

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引用次数: 0

Abstract

Introduction

Senile dementia of the neurofibrillary tangle type (SD-NFT) is a subset of dementia in elderly individuals. Recent studies have reported a correlation between hippocampal sclerosis (HS) and aging. This study aimed to investigate the relationship between HS and SD-NFT.

Methods

We conducted a clinical and neuropathological review of Japanese patients diagnosed with SD-NFT. Hematoxylin–eosin and Klüver–Barrera staining, Gallyas silver impregnation, and immunohistochemistry were employed. Pathological assessments focused on identifying HS, neuritic plaques, and phosphorylated transactive response DNA-binding protein 43 (p-TDP-43)-positive inclusions. Additionally, we quantified the densities of neurofibrillary tangles (NFTs) and ghost tangles (GTs) within the hippocampal CA1 region.

Results

Nine patients met the criteria for SD-NFT from the patients who underwent consecutive autopsies from 1994 to 2022 at our institute. The mean ages at onset and death were 84.0 ± 6.8 years (range, 76–94 years) and 91.0 ± 7.0 years (range, 79–101 years), respectively. The mean dementia duration was 7.0 ± 4.0 years (range, 1–13 years). All patients exhibited memory loss although none were diagnosed with SD-NFT during their lifetime. The mean brain weight was 1124.2 ± 132.1 g (range, 980–1390 g). Three patients displayed HS. NFT and GT densities were significantly higher in patients with HS than in those without HS. No significant correlation was found between HS and p-TDP-43 inclusions in the medial temporal lobe.

Conclusion

In SD-NFT, NFTs are more strongly associated with HS. This finding enhances our understanding of the pathological underpinnings of HS in SD-NFT.

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来源期刊

Journal of the Neurological Sciences 医学-临床神经学

CiteScore

7.60

自引率

2.30%

发文量

313

审稿时长

22 days

期刊介绍： The Journal of the Neurological Sciences provides a medium for the prompt publication of original articles in neurology and neuroscience from around the world. JNS places special emphasis on articles that: 1) provide guidance to clinicians around the world (Best Practices, Global Neurology); 2) report cutting-edge science related to neurology (Basic and Translational Sciences); 3) educate readers about relevant and practical clinical outcomes in neurology (Outcomes Research); and 4) summarize or editorialize the current state of the literature (Reviews, Commentaries, and Editorials). JNS accepts most types of manuscripts for consideration including original research papers, short communications, reviews, book reviews, letters to the Editor, opinions and editorials. Topics considered will be from neurology-related fields that are of interest to practicing physicians around the world. Examples include neuromuscular diseases, demyelination, atrophies, dementia, neoplasms, infections, epilepsies, disturbances of consciousness, stroke and cerebral circulation, growth and development, plasticity and intermediary metabolism.