Excitation wavelength dependent multiple biomolecule SERS responses from Bi/ZnO thin films towards ultrasensitive Hemoglobin and L-tyrosine detections

IF 2.4 4区物理与天体物理 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Current Applied Physics Pub Date : 2025-02-17 DOI:10.1016/j.cap.2025.02.008

Risa Marium Philip, D. Bharathi Mohan

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Abstract

Fabricated Bi/ZnO bilayer thin films enhances the surface plasmon coupling, creating a superhydrophobic Surface Enhanced Raman Scattering (SERS) platform. The excitation wavelengths, 532 and 785 nm were selected to balance the signal intensity and minimal fluorescence interference, towards improving the detection accuracy across a range of biomarkers from monomers to complex proteins. The films consist of columnar wurtzite ZnO base with orthorhombic metallic Bi on top. The minimal chemical changes at Bi: ZnO interface, confines the local electric field to surface. Cancer and neurodegenerative biomarkers, Hemoglobin (Hb) and L-tyrosine (Tyr), studied for Limit of Detection (LoD) using respective laser achieved, a 10 fM LoD with SERS enhancement factor (EF) of 8.42 x 10¹¹ for Hb (532 nm), and a 10 aM LoD with 6.60 x 10¹⁵ SERS EF for Tyr (785 nm). These unprecedented detection thresholds demonstrate the ultrasensitive detection capabilities of the fabricated SERS platform for early medical diagnosis.

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来源期刊

Current Applied Physics 物理-材料科学：综合

CiteScore

4.80

自引率

0.00%

发文量

213

审稿时长

33 days

期刊介绍： Current Applied Physics (Curr. Appl. Phys.) is a monthly published international journal covering all the fields of applied science investigating the physics of the advanced materials for future applications. Other areas covered: Experimental and theoretical aspects of advanced materials and devices dealing with synthesis or structural chemistry, physical and electronic properties, photonics, engineering applications, and uniquely pertinent measurement or analytical techniques. Current Applied Physics, published since 2001, covers physics, chemistry and materials science, including bio-materials, with their engineering aspects. It is a truly interdisciplinary journal opening a forum for scientists of all related fields, a unique point of the journal discriminating it from other worldwide and/or Pacific Rim applied physics journals. Regular research papers, letters and review articles with contents meeting the scope of the journal will be considered for publication after peer review. The Journal is owned by the Korean Physical Society.