Sex-specific risks for cardiovascular disease across the specific depressive symptoms spectrum: A national prospective cohort study

IF 4.1 2区医学 Q1 PSYCHIATRY

General hospital psychiatry Pub Date : 2025-02-13 DOI:10.1016/j.genhosppsych.2025.02.006

Yu-Hua Liu , Lu Zhai , Rong-Rui Huo , Cui Ma

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引用次数: 0

Abstract

Background

To examine sex-specific risks for cardiovascular disease across the specific depressive symptoms spectrum: a national prospective cohort in China.

Methods

Using data from the China Health and Retirement Longitudinal Study (CHARLS), involving 11,735 individuals aged 45 and older in China. Ten specific depressive symptoms, assessed at baseline using the CES-D short form. Cox proportional hazard models estimated hazard ratios (HRs) for each symptom's association with CVD.

Results

During the 7 years of follow-up, 1246 (20.8 %) incident CVD cases were identified among women, compared to 985 (17.1 %) among men. All ten specific depressive symptoms exhibited a higher incidence in women than in men. Nine of these symptoms were associated with an increased risk of CVD in both sexes. Restless sleep was more strongly associated with CVD in women (HR, 1.44; 95 % CI, 1.28–1.62) than in men (HR, 1.18; 95 % CI, 1.04–1.34) at baseline (P = 0.013 for interaction), whereas the HRs for other specific depressive symptoms were similar among women and men. Loneliness was the most important symptom for CVD risk in men, while restless sleep was the most significant for women.

Conclusions

Nine of 10 specific depressive symptoms may increase the risk of CVD in Chinese adults, regardless of gender. Notably, the association between restless sleep and CVD was strong in women, while loneliness showed a stronger association with CVD in men. These findings highlight the importance of considering specific depressive symptoms in assessing CVD risk among middle-aged and older adults, particularly across sexes.

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特定抑郁症状谱系中心血管疾病的性别特异性风险：一项全国前瞻性队列研究

背景：研究特定抑郁症状谱系中心血管疾病的性别特异性风险：中国的一项全国前瞻性队列研究。方法使用中国健康与退休纵向研究（CHARLS）的数据，涉及11,735名年龄在45岁及以上的中国人。10种特定的抑郁症状，在基线时使用简短的CES-D量表进行评估。Cox比例风险模型估计了每种症状与心血管疾病相关的风险比（hr）。结果在7年的随访中，女性中发现1246例（20.8%）心血管疾病病例，而男性中发现985例（17.1%）。所有10种特定抑郁症状在女性中的发生率均高于男性。其中9种症状与心血管疾病的风险增加有关。不安稳睡眠与女性心血管疾病的相关性更强(HR, 1.44；95% CI, 1.28-1.62)高于男性(HR, 1.18；95% CI, 1.04-1.34)（相互作用的P = 0.013），而其他特定抑郁症状的hr在女性和男性中相似。孤独是男性心血管疾病风险最重要的症状，而睡眠不安稳对女性来说是最重要的。结论在中国成年人中，10种特定抑郁症状中的9种可能增加CVD的风险，而不受性别的影响。值得注意的是，不安的睡眠和心血管疾病之间的联系在女性中很强，而孤独与心血管疾病在男性中表现出更强的联系。这些发现强调了在评估中老年人心血管疾病风险时考虑特定抑郁症状的重要性，尤其是跨性别的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

General hospital psychiatry 医学-精神病学

CiteScore

9.60

自引率

2.90%

发文量

125

审稿时长

20 days

期刊介绍： General Hospital Psychiatry explores the many linkages among psychiatry, medicine, and primary care. In emphasizing a biopsychosocial approach to illness and health, the journal provides a forum for professionals with clinical, academic, and research interests in psychiatry''s role in the mainstream of medicine.