Simple introduced in/on preformed macrocyclic ligands with imidazole groups as new platform linkers in metal-organic frameworks material: Application in electrochemical sensing Losartan

Abstract

In this paper, macrocycle compounds containing nitrogen and oxygen groups were synthesized via template condensation of o-phenylenediamine with various aromatic dicarboxylic acids. In the following stage, to create an appropriate linker for the formation of metal-organic frameworks (MOFs), the obtained macrocyclic compound was reacted with 4-chloro 2-methylimidazole derivatives in a straightforward reaction. A new metal-organic frameworks (MOFs) was formed by the interaction of Co (II) ions with a macrocyclic ligand, specifically the Zeolitic imidazolate framework macrocyclic ligand metal-organic frameworks (ZIF-MLMOFs). The synthesized compounds were thoroughly characterized using various physicochemical methods, including melting point determination and elemental analysis techniques such as XRD, NMR, and FT-IR spectroscopy. The results obtained were consistent with the proposed structures. In order to apply the synthetic material, the electrochemical technique was used for investigation of Losartan (LOS) drug sample. Subsequently, the catalytic activity of ZIF-MLMOFs/Nf/GCE was characterized by cyclic voltammetry (CV) and chronoamperometry (CA) for the oxidation of LOS in PBs media. The diffusion coefficient of LOS was found to be (D_LOS =7.94×10⁻⁶ cm² s⁻¹) and the catalytic rate constant was measured as (k_cat = 1.75×10⁶ cm³ mol⁻¹ s⁻¹). Differential pulse voltammetry (DPV) exhibited a linear response range of 1.99–100 μM with a limit of detection of 0.76 μM. The electrochemical sensor exhibited exceptional selectivity and sensitivity, along with reproducibility and repeatability, which can enhance the application of MOFs in drug electrochemical sensors.