Multi-Omics Analysis Reveals Potential Mechanisms of Diarrhetic Shellfish Toxin and Fatty Acid Synthesis in Marine Harmful Prorocentrum

IF 12.2 1区环境科学与生态学 Q1 ENGINEERING, ENVIRONMENTAL

Journal of Hazardous Materials Pub Date : 2025-02-21 DOI:10.1016/j.jhazmat.2025.137674

Danlin Zheng, Ligong Zou, Jian Zou, Qun Li, Songhui Lu

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Abstract

This study integrates transcriptomic and proteomic approaches to investigate the synthesis pathways of diarrhetic shellfish toxins (DSTs) in Prorocentrum lima and Prorocentrum arenarium, three strains exhibiting distinct toxin profiles. By combining multi-omics data, we identified 45 type I polyketide synthases (PKSs) and 45 type II fatty acid synthases (FASs) as potential candidates involved in DST production. Sequence analysis of the selected PKS and FAS genes revealed a high level of consistency across different omics datasets. Our results highlight the differential expression of proteins associated with fatty acid biosynthesis, with P. arenarium (HN231) exhibiting a significantly higher proportion of saturated fatty acids (SFAs) compared to P. lima (3XS36 and XS336), consistent with the upregulation of proteins involved in fatty acid synthesis pathways. These findings offer new insights into the molecular mechanisms underlying DST production and fatty acid metabolism in dinoflagellates, providing a foundation for future research on environmental contamination by DSTs. This study underscores the importance of multi-omics approaches for understanding hazardous marine toxins and their environmental implications.

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来源期刊

Journal of Hazardous Materials 工程技术-工程：环境

CiteScore

25.40

自引率

5.90%

发文量

3059

审稿时长

58 days

期刊介绍： The Journal of Hazardous Materials serves as a global platform for promoting cutting-edge research in the field of Environmental Science and Engineering. Our publication features a wide range of articles, including full-length research papers, review articles, and perspectives, with the aim of enhancing our understanding of the dangers and risks associated with various materials concerning public health and the environment. It is important to note that the term "environmental contaminants" refers specifically to substances that pose hazardous effects through contamination, while excluding those that do not have such impacts on the environment or human health. Moreover, we emphasize the distinction between wastes and hazardous materials in order to provide further clarity on the scope of the journal. We have a keen interest in exploring specific compounds and microbial agents that have adverse effects on the environment.