Depression, reduced physical activity and the risk of heart disease: a prospective cohort of European middle-aged and older adults

IF 11.6 1区医学 Q1 SPORT SCIENCES

British Journal of Sports Medicine Pub Date : 2025-02-20 DOI:10.1136/bjsports-2024-108780

Miguel Peralta, Marcelo Nascimento, Gerson Ferrari, Élvio R. Gouveia, Adilson Marques

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引用次数: 0

Abstract

Objective To assess the impact of depression and physical activity (PA) of different intensities on the incidence of heart disease. Methods A prospective cohort study with 20 645 European middle-aged and older adults (mean baseline age 63 years; 55.1% women; median follow-up 9.5 years) was conducted using data from the Survey of Health, Ageing and Retirement in Europe. The EURO-D 12-item scale assessed depression. Moderate-intensity and vigorous-intensity PA and heart disease diagnoses were self-reported. We classified participants into the following four groups: (1) depression plus low PA, (2) no depression plus low PA, (3) depression plus moderate/high PA, (4) no depression plus moderate/high PA. Hazard ratio (HR) and 95% confidence interval (CI) were estimated using Cox proportional hazards models adjusted for confounders. Results Compared with having depression and low PA levels, adjusted HR for heart disease similarly decreased for participants with depression and moderate/high PA (moderate-intensity PA: HR=0.63, 95% CI=0.50, 0.78; vigorous-intensity PA: HR=0.69, 95% CI=0.53, 0.89) and participants without depression and low PA (moderate-intensity PA: HR=0.64, 95% CI=0.50, 0.82; vigorous-intensity PA: HR=0.68, 95% CI=0.58, 0.80). The greatest risk reduction was found in participants without depression and moderate/high PA (moderate-intensity PA: HR=0.46, 95% CI=0.37, 0.55; vigorous-intensity PA: HR=0.48, 95% CI=0.40, 0.58). Conclusion Moderate-intensity and vigorous-intensity PA seems to counteract the increased risk for heart disease associated with depression. This highlights the importance of PA as a possible intervention strategy aiming to manage the risk of heart disease among people with depression. Data are available upon reasonable request. The SHARE databases were assessed by registering and accepting the SHARE Research Data Center at as long as the data is used for scientific purposes.

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抑郁、体力活动减少和心脏病风险：欧洲中老年人群的前瞻性队列研究

目的探讨不同强度的抑郁和体育锻炼对心脏病发病率的影响。方法一项前瞻性队列研究，纳入20645名欧洲中老年人(平均基线年龄63岁；55.1%的女性;（中位随访时间为9.5年）使用欧洲健康、老龄化和退休调查的数据进行研究。EURO-D 12项量表评估抑郁症。中等强度和高强度PA和心脏病诊断均为自我报告。我们将参与者分为以下四组：(1)抑郁加低PA，(2)无抑郁加低PA，(3)抑郁加中/高PA，(4)无抑郁加中/高PA。使用校正混杂因素的Cox比例风险模型估计风险比（HR）和95%置信区间（CI）。结果与抑郁和低PA水平的受试者相比，抑郁和中/高PA水平的受试者心脏病的调整HR同样降低(中强度PA: HR=0.63, 95% CI=0.50, 0.78；高强度PA: HR=0.69, 95% CI=0.53, 0.89)和无抑郁且低PA的参与者(中等强度PA: HR=0.64, 95% CI=0.50, 0.82；高强度PA: HR=0.68, 95% CI=0.58, 0.80)。无抑郁和中/高PA的受试者风险降低最大(中强度PA: HR=0.46, 95% CI=0.37, 0.55；高强度PA: HR=0.48, 95% CI=0.40, 0.58)。结论中等强度和高强度PA似乎可以抵消抑郁症相关心脏病风险的增加。这突出了PA作为一种可能的干预策略的重要性，旨在控制抑郁症患者患心脏病的风险。如有合理要求，可提供资料。只要数据用于科学目的，就通过注册和接受SHARE研究数据中心对SHARE数据库进行评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British Journal of Sports Medicine 医学-运动科学

CiteScore

27.10

自引率

4.90%

发文量

217

审稿时长

3-8 weeks

期刊介绍： The British Journal of Sports Medicine (BJSM) is a dynamic platform that presents groundbreaking research, thought-provoking reviews, and meaningful discussions on sport and exercise medicine. Our focus encompasses various clinically-relevant aspects such as physiotherapy, physical therapy, and rehabilitation. With an aim to foster innovation, education, and knowledge translation, we strive to bridge the gap between research and practical implementation in the field. Our multi-media approach, including web, print, video, and audio resources, along with our active presence on social media, connects a global community of healthcare professionals dedicated to treating active individuals.