Compartmentalization of multilayer microreactors using protein-polymer hybrids

IF 4.5 2区化学 Q2 POLYMER SCIENCE

Polymer Pub Date : 2025-02-21 DOI:10.1016/j.polymer.2025.128182

Irene Alonso-Sampedro , Aitor Larrañaga , Ana Beloqui

引用次数: 0

Abstract

The application of a layer-by-layer approach for stabilizing inorganic particles, such as calcium carbonate, with polyelectrolytes leads to the formation of core-shell architectures that create distinct environments for protein confinement. In this study, we propose embedding enzymes within the polymeric shell by synthesizing polymer-enzyme hybrids. These hybrids are designed to be effectively entrapped among the polymer layers through electrostatic interactions. Consequently, we have investigated the localization of enzymes within the various confinements provided by layered particles and evaluated their potential to function as catalytic microreactors.

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用蛋白质-聚合物杂化物划分多层微反应器

应用一层一层的方法来稳定无机颗粒，如碳酸钙，用聚电解质导致核壳结构的形成，为蛋白质限制创造了独特的环境。在这项研究中，我们提出通过合成聚合物-酶杂化物将酶嵌入聚合物壳内。这些杂化体被设计成通过静电相互作用有效地包裹在聚合物层之间。因此，我们研究了酶在层状颗粒提供的各种限制内的定位，并评估了它们作为催化微反应器的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Polymer 化学-高分子科学

CiteScore

7.90

自引率

8.70%

发文量

959

审稿时长

32 days

期刊介绍： Polymer is an interdisciplinary journal dedicated to publishing innovative and significant advances in Polymer Physics, Chemistry and Technology. We welcome submissions on polymer hybrids, nanocomposites, characterisation and self-assembly. Polymer also publishes work on the technological application of polymers in energy and optoelectronics. The main scope is covered but not limited to the following core areas: Polymer Materials Nanocomposites and hybrid nanomaterials Polymer blends, films, fibres, networks and porous materials Physical Characterization Characterisation, modelling and simulation* of molecular and materials properties in bulk, solution, and thin films Polymer Engineering Advanced multiscale processing methods Polymer Synthesis, Modification and Self-assembly Including designer polymer architectures, mechanisms and kinetics, and supramolecular polymerization Technological Applications Polymers for energy generation and storage Polymer membranes for separation technology Polymers for opto- and microelectronics.