Strong Bioadhesives from Helical Polypeptides

IF 5.1 Q1 POLYMER SCIENCE

ACS Macro Letters Pub Date : 2025-02-21 DOI:10.1021/acsmacrolett.5c00021

Jiangyan Shi, Liufen Kong, Ning Wang, Zhimin Li, Chuanzhuang Zhao, Chongyi Chen

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Abstract

Bioadhesives have emerged as versatile and powerful tools for tissue repair and integration with biomedical devices, offering a wide range of applications that have captured significant clinical and scientific interest. Synthetic polypeptide adhesives are particularly promising candidates for bioadhesives, but often face limitations in adhesive strength. In this study, inspired by marine adhesive proteins, the secondary structure and hydrophobic–hydrophilic balance of polypeptides were precisely regulated to transform the polyelectrolyte to a strong adhesive. The resulting polypeptide adhesive demonstrated an adhesive strength exceeding 1.0 MPa, more than 10× higher than that of the previously reported synthetic polypeptide adhesive. The cohesion and adhesion of polypeptide adhesive can be optimized by adjusting the content of the secondary structure and hydrophobic residue ratios. More helices in polypeptides enhance the interactions between the polypeptide backbone and side chains as well as the interactions between polypeptides and substrates. In addition, these polypeptide adhesives exhibit excellent tolerance to strong acids or alkalis, remarkable adhesion to variable materials and tissues, and an impressive sealing performance.

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来源期刊

ACS Macro Letters 化学-

CiteScore

10.40

自引率

3.40%

发文量

209

审稿时长

1 months

期刊介绍： ACS Macro Letters publishes research in all areas of contemporary soft matter science in which macromolecules play a key role, including nanotechnology, self-assembly, supramolecular chemistry, biomaterials, energy generation and storage, and renewable/sustainable materials. Submissions to ACS Macro Letters should justify clearly the rapid disclosure of the key elements of the study. The scope of the journal includes high-impact research of broad interest in all areas of polymer science and engineering, including cross-disciplinary research that interfaces with polymer science. With the launch of ACS Macro Letters, all Communications that were formerly published in Macromolecules and Biomacromolecules will be published as Letters in ACS Macro Letters.