Quantitative ultrasound analysis for non-invasive assessment of hepatic steatosis in metabolic dysfunction-associated steatotic liver disease.

Yunling Fan, Kailing Chen, Qiannan Zhao, Haohao Yin, Yuli Zhu, Huixiong Xu
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Abstract

Objective: To evaluate the diagnostic performance of novel tissue attenuation imaging (TAI) and tissue scatter distribution imaging (TSI) tools in detecting and grading hepatic steatosis using controlled attenuation parameter (CAP) as reference standard.

Methods: A total of 185 participants with suspected metabolic dysfunction-associated steatotic liver disease (MASLD) were prospectively enrolled, and all underwent CAP and quantitative ultrasound (QUS) testing. Correlations between CAP, biological data, TAI and TSI were assessed. The influence factors of TAI and TSI as well as the diagnostic performance of TAI and TSI in detecting hepatic steatosis were evaluated.

Results: The QUS parameters (TAI and TSI) showed good intra-observer reliability with ICC of 0.972 and 0.777, respectively. The correlation of CAP with TAI was higher than that of TSI (0.724 vs 0.360, P < 0.05). Multivariate Regression analysis showed that CAP was an important influence factor of TAI and TSI (P < 0.001). The area under the ROC curve (CAP > 250 dB/m) of TAI and TSI tools for detecting hepatic steatosis was 0.876 (95% CI: 0.813-0.923; P < 0.0001) and 0.797(95% CI: 0.724-0.857; P < 0.001), respectively; the sensitivity was 67.18% and 83.21%, the specificity was 95.65% and 69.57%, and the cut-off values were 0.93 dB/cm/MHz and 91.28, respectively. When TAI and TSI were combined, the area under the ROC curve was 0.881, with a sensitivity of 80.92% and a specificity of 82.61%. The Delong test showed that the combined diagnosis of TAI and TSI was equivalent to the use of TAI alone (P > 0.05).

Conclusion: TAI and TSI provided good intra-observer reliability, correlated well with CAP, and helped to detect and stage hepatic steatosis.

定量超声分析在无创评估代谢功能障碍相关的脂肪肝疾病中的肝脂肪变性。
目的:评价以控制衰减参数(CAP)为参考标准的新型组织衰减成像(TAI)和组织散射分布成像(TSI)工具对肝脂肪变性的诊断价值。方法:共纳入185名疑似代谢功能障碍相关脂肪变性肝病(MASLD)的参与者,所有参与者均接受CAP和定量超声(QUS)检测。评估CAP、生物学数据、TAI和TSI之间的相关性。评价TAI和TSI的影响因素以及TAI和TSI对肝脂肪变性的诊断价值。结果:QUS参数(TAI和TSI)具有良好的观察者内信度,ICC分别为0.972和0.777。CAP与TAI的相关性高于TSI (0.724 vs 0.360, P P 250 dB/m), TSI检测肝脂肪变性工具的相关性为0.876 (95% CI: 0.813-0.923;p p p > 0.05)。结论:TAI和TSI具有良好的观察者内信度,与CAP相关性良好,有助于肝脂肪变性的发现和分期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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