Evaluation of the Factors Influencing the Survival Times of Chinese Patients with Probable Creutzfeldt-Jacob Disease - China, 2020-2022.

IF 4.3 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

中国疾病预防控制中心周报 Pub Date : 2025-02-14 DOI:10.46234/ccdcw2025.040

Weiwei Zhang, Yuan Wang, Ruhan A, Donglin Liang, Kang Xiao, Donghua Zhou, Xiaoxi Jia, Bing Xu, Rundong Cao, Cao Chen, Xiaoping Dong, Qi Shi

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引用次数: 0

Abstract

What is already known about this topic?: The clinical durations of sporadic Creutzfeldt-Jacob disease (sCJD) patients typically do not exceed 2 years, though considerable variation exists. The factors influencing survival among Chinese sCJD patients remain incompletely characterized.

What is added by this report?: A comprehensive evaluation of 31 factors across 7 categories was conducted in a retrospective cohort of 300 probable Chinese sCJD patients. The analysis revealed that patients over 65 years of age at onset, those presenting with pyramidal or extrapyramidal dysfunction, those showing high signal intensity in caudate/putamen on magnetic resonance imaging, and those not receiving nasal feeding demonstrated significantly shorter survival times.

What are the implications for public health practice?: This study provides the first systematic documentation of potential risk factors affecting survival times in Chinese sCJD patients, establishing an evidence base for developing and implementing targeted intervention strategies.

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来源期刊

中国疾病预防控制中心周报

CiteScore

5.90

自引率

0.00%

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