Comparison of vHIT deficits with Ramsay Hunt syndrome with dizziness, vestibular neuritis, and idiopathic sudden sensorineural hearing loss with vertigo.

IF 2.9 3区 医学 Q2 NEUROSCIENCES
Yingzhao Liu, Xiaoye Chen, Xingqian Shen, Kaijun Xia, Qin Liu, Renhong Zhou, Yangming Leng, Hongjun Xiao, Bo Liu
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引用次数: 0

Abstract

Background: Ramsay Hunt syndrome with dizziness (RHSD), vestibular neuritis (VN), and idiopathic sudden sensorineural hearing loss with vertigo (SHLV) all present with acute vestibular symptoms, and no study has compared the semicircular canal (SCC) deficits among them.

Objective: This study aimed to use video head impulse test (vHIT) to compare the SCC injury patterns in RHSD, VN, and SHLV.

Methods: Twenty-three RHSD patients, 44 VN patients, and 70 SHLV patients were enrolled. The vestibulo-ocular reflex gain and incidence of corrective saccades of anterior, horizontal, and posterior SCC (ASCC, HSCC, and PSCC) were examined using vHIT. Pathological vHIT results referred to decreased VOR gain and presence of corrective saccades.

Results: (1) The pathological rate of each SCC in RHSD group was the highest. (2) Impairment pattern of SCCs can be divided into 7 types based on vHIT results. The pattern of ASCC + HSCC + PSCC disability was the most common in RHSD patients (12/23, 52.2%). In the VN group, the HSCC deficit alone was the most common (16/44, 36.4%), followed by HSCC + ASCC impairment (13/44, 29.5%). In SHLV patients, the most common type was the PSCC deficit alone (26/70, 37.1%). (3) The system cluster analysis revealed that the injury of all SCCs in RHSD patients, the deficit of HSCC alone in VN patients, and the impairment of PSCC alone in SHLV patients showed the farthest distance from other injury patterns.

Conclusion: SCCs deficit showed more severe and extensive vestibular impairment in RHSD compared with VN and SHLV, suggesting these three peripheral acute vestibular disorders may have different pathophysiologic mechanisms.

vHIT 缺陷与伴有眩晕的拉姆齐-亨特综合征、前庭神经炎和特发性突发性感音神经性听力损失伴眩晕的比较。
背景:Ramsay Hunt综合征合并头晕(RHSD)、前庭神经炎(VN)和特发性突发性感音神经性听力损失合并眩晕(SHLV)均表现为急性前庭症状,但尚未有研究比较它们之间的半圆形管(SCC)缺陷。目的:采用视频脑脉冲试验(vHIT)比较RHSD、VN和SHLV的SCC损伤模式。方法:纳入23例RHSD患者、44例VN患者和70例SHLV患者。使用vHIT检查前庭-眼反射增益和前、水平和后鳞状细胞癌(ASCC、HSCC和PSCC)矫正性扫视的发生率。病理vHIT结果涉及到VOR增益降低和矫正性眼跳的存在。结果:(1)RHSD组各SCC的病理发生率最高。(2)基于vHIT结果,SCCs的损伤模式可分为7种类型。ASCC + HSCC + PSCC残疾模式在RHSD患者中最为常见(12/23,52.2%)。在VN组中,仅HSCC缺陷最为常见(16/44,36.4%),其次是HSCC + ASCC损伤(13/44,29.5%)。在SHLV患者中,最常见的类型是单独的PSCC缺陷(26/70,37.1%)。(3)系统聚类分析显示,RHSD患者的所有scc损伤、VN患者的单独HSCC缺陷和SHLV患者的单独PSCC损伤与其他损伤模式的距离最远。结论:与VN和SHLV相比,SCCs缺损在RHSD中表现出更为严重和广泛的前庭功能损害,提示这三种周围性急性前庭功能障碍可能具有不同的病理生理机制。
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来源期刊
CiteScore
5.00
自引率
4.30%
发文量
66
审稿时长
>12 weeks
期刊介绍: Journal of Vestibular Research is a peer-reviewed journal that publishes experimental and observational studies, review papers, and theoretical papers based on current knowledge of the vestibular system. Subjects of the studies can include experimental animals, normal humans, and humans with vestibular or other related disorders. Study topics can include the following: Anatomy of the vestibular system, including vestibulo-ocular, vestibulo-spinal, and vestibulo-autonomic pathways Balance disorders Neurochemistry and neuropharmacology of balance, both at the systems and single neuron level Neurophysiology of balance, including the vestibular, ocular motor, autonomic, and postural control systems Psychophysics of spatial orientation Space and motion sickness Vestibular rehabilitation Vestibular-related human performance in various environments
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